Earl of Bothwell was a title that was created twice in the Peerage of Scotland. It was first created for Patrick Hepburn in 1488, and was forfeited in 1567. Subsequently, the earldom was re-created for the 4th Earl's nephew and heir of line, Francis Stewart, whose father was an illegitimate son of James V. The second creation was forfeited in 1612, and although the heir was subsequently rehabilitated, the title was never restored.
The title Duke of Orkney was created in the Peerage of Scotland in 1567 for James Hepburn, 4th Earl of Bothwell, with the subsidiary title Marquess of Fife. All titles were declared forfeit in 1567.