Eastern Sephardim are a distinctive sub-group of Sephardic Jews mostly descended from Jewish families which were exiled from Iberia in the 15th century, following the Alhambra Decree of 1492 in Spain and a similar decree in Portugal five years later. This branch of descendants of Iberian Jews settled across the Eastern Mediterranean.
Eastern Sephardim mostly settled in various parts of the Ottoman Empire, which included areas in West Asia (Middle East, Anatolia, etc.), the Balkans in Southern Europe, plus Egypt. For centuries, these Jews made up the majority of the population of Salonica (now Thessaloniki, Greece) and were present in large numbers in Constantinople (now Istanbul, Turkey) and Sarajevo (in what is now Bosnia and Herzegovina), all of which were located in the Ottoman-ruled parts of Europe.
Some migrated farther east to the territories of the Ottoman Empire, settling among the long-established Arabic-speaking Jewish communities of Baghdad in Iraq, Damascus in Syria and Alexandria in Egypt. A few of the Eastern Sephardim followed the spice trade routes as far as the Malabar coast of southern India, where they settled among the established Cochin Jewish community, again, they imparted their culture and their customs to the local Jews. The presence of Sephardim and New Christians along the Malabar coast eventually aroused the ire of the Catholic Church, which then obtained permission from the Portuguese crown to establish the Goan Inquisition against the Sephardic Jews of India.
In recent times, principally after 1948, most Eastern Sephardim have relocated to Israel, and others have relocated to the United States, France and Latin America.