Ecdysone receptor

Ecdysone receptor protein
Crystallographic structure of the ligand binding domain of the ecdysone receptor (rainbow color, N-terminus = blue, C-terminus = red) from Heliothis virescens complexed with ponasterone A (space-filling model, carbon = white, oxygen = red).[1]
Identifiers
Organism	Drosophila melanogaster
Symbol	EcR
Alt. symbols	EcRH, NR1H1
Entrez	35540
PDB	1R0O More structures
RefSeq (mRNA)	NM_165461
RefSeq (Prot)	NP_724456
UniProt	P34021
Other data
Chromosome	2R: 1.97 - 2.07 Mb
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Ultraspiracle protein
Ultraspiracle ligand binding domain. PDB 1hg4 [2]
Identifiers
Organism	Drosophila melanogaster
Symbol	USP
Alt. symbols	Cf1, NR2B4
Entrez	31165
PDB	1HG4 More structures
RefSeq (mRNA)	NM_057433
RefSeq (Prot)	NP_476781
UniProt	P20153
Other data
Chromosome	X: 1.93 - 1.94 Mb
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The ecdysone receptor is a nuclear receptor found in arthropods, where it controls development and contributes to other processes such as reproduction. The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). It binds to and is activated by ecdysteroids. Insect ecdysone receptors are currently better characterized than those from other arthropods, and mimics of ecdysteroids are used commercially as caterpillar-selective insecticides.