Edwin Holmes may refer to:
- Edwin R. Holmes (1878–1961), United States federal judge
- Edwin Holmes (inventor) (1820–1901), American businessman credited with commercializing the electromagnetic burglar alarm
- Edwin Holmes (astronomer) (1839–1919), English amateur astronomer
- Edwin N. Holmes, head football coach for the Middlebury College Panthers football team, 1915–1917
This disambiguation page lists articles about people with the same name.
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