Elongation factor for RNA polymerase II 2

ELL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E5N
Identifiers
Aliases	ELL2, elongation factor for RNA polymerase II 2, MRCCAT1
External IDs	OMIM: 601874; MGI: 2183438; HomoloGene: 8094; GeneCards: ELL2; OMA:ELL2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	95,961,851 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	75,920,483 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; mucosa of paranasal sinus; ; cartilage tissue; ; Achilles tendon; ; islet of Langerhans; ; pancreatic epithelial cell; ; gums; ; oral cavity; ; gingival epithelium; ; lower lobe of lung;
	Top expressed in
	seminal vesicula; ; lacrimal gland; ; parotid gland; ; submandibular gland; ; molar; ; blood; ; epithelium of lens; ; epithelium of stomach; ; human fetus; ; body of femur;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	nucleus; transcription elongation factor complex; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; transcription elongation from RNA polymerase II promoter; snRNA transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	22936
	192657
	ENSG00000118985
	ENSMUSG00000001542
	O00472
	Q3UKU1
	NM_012081
	NM_138953
	NP_036213
	NP_620403
	Wikidata
View/Edit Human	View/Edit Mouse

Elongation factor for RNA polymerase II 2 is a protein that in humans is encoded by the ELL2 gene. ^[5]

The encoded protein is a component of the superelongation complex (SEC) and drives immunoglobulin synthesis in plasma cells. Sequence variation in ELL2 has been associated with multiple myeloma and altered immunoglobulin levels.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118985 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001542 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Elongation factor for RNA polymerase II 2". Retrieved 2018-08-24.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118985 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001542 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Elongation factor for RNA polymerase II 2". Retrieved 2018-08-24.

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