Eluxadoline

Eluxadoline
Clinical data
PronunciationViberzi (/vaɪˈbɜːrzi/ vy-BUR-zee
Trade namesViberzi, Truberzi
Other namesJNJ-27018966
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding81%
Elimination half-life3.7–6 hours
Excretion82.2% (feces), <1% (urine)[2]
Identifiers
  • 5-({[(2S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)propanoyl] [(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC32H35N5O5
Molar mass569.662 g·mol−1
3D model (JSmol)
  • CC1=CC(=CC(=C1CC(C(=O)N(CC2=CC(=C(C=C2)OC)C(=O)O)C(C)C3=NC=C(N3)C4=CC=CC=C4)N)C)C(=O)N
  • InChI=1S/C32H35N5O5/c1-18-12-23(29(34)38)13-19(2)24(18)15-26(33)31(39)37(17-21-10-11-28(42-4)25(14-21)32(40)41)20(3)30-35-16-27(36-30)22-8-6-5-7-9-22/h5-14,16,20,26H,15,17,33H2,1-4H3,(H2,34,38)(H,35,36)(H,40,41)/t20-,26-/m0/s1
  • Key:QFNHIDANIVGXPE-FNZWTVRRSA-N

Eluxadoline, sold under the brand names Viberzi and Truberzi,[3] is a medication taken by mouth for the treatment of diarrhea and abdominal pain in individuals with diarrhea-predominant irritable bowel syndrome (IBS-D).[4] It was approved for use in the United States in 2015.[5] The drug originated from Janssen Pharmaceutica and was developed by Actavis.

  1. ^ "Digestive and bladder health". Health Canada. 9 May 2018. Retrieved 13 April 2024.
  2. ^ "Viberzi (eluxadoline) Tablets, for Oral Use, CIV. Full Prescribing Information". Actavis Pharma, Inc. Parsippany, NJ 07054 USA. Archived from the original on 27 December 2015. Retrieved 26 December 2015.
  3. ^ "Truberzi". European Medicines Agency. 29 September 2016. Archived from the original on 21 September 2017. Retrieved 28 June 2017.
  4. ^ Fragkos KC (2017-09-25). "Spotlight on eluxadoline for the treatment of patients with irritable bowel syndrome with diarrhea". Clinical and Experimental Gastroenterology. 10: 229–240. doi:10.2147/ceg.s123621. PMC 5624596. PMID 28989282.
  5. ^ "FDA approves two therapies to treat IBS-D". www.fda.gov. Retrieved 2015-06-01.