Emtricitabine/tenofovir

This article is about the combination medication emtricitabine/tenofovir disoproxil. For the combination medication emtricitabine/tenofovir alafenamide, see Tenofovir alafenamide § combinations.

Emtricitabine/tenofovir
Combination of
EmtricitabineNucleoside reverse transcriptase inhibitor
Tenofovir disoproxilNucleotide analogue reverse transcriptase inhibitor
Clinical data
Trade namesTruvada, others
Other namesEmtricitabine/tenofovir disoproxil fumarate
AHFS/Drugs.comMonograph
MedlinePlusa612036
License data
Pregnancy
category
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
KEGG
NIAID ChemDB
  (verify)

Emtricitabine/tenofovir, sold under the brand name Truvada among others, is a fixed-dose combination antiretroviral medication used to treat and prevent HIV/AIDS.[5][6] It contains the antiretroviral medications emtricitabine and tenofovir disoproxil.[7] For treatment, it must be used in combination with other antiretroviral medications.[7][8] For prevention before exposure, in those who are at high risk, it is recommended along with safer sex practices.[7] It does not cure HIV/AIDS.[5] Emtricitabine/tenofovir is taken by mouth.[7]

Common side effects include headache, tiredness, trouble sleeping, abdominal pain, weight loss, and rash.[5] Serious side effects may include high blood lactate levels and enlargement of the liver.[7] Use of this medication during pregnancy does not appear to harm the fetus, but this has not been well studied.[1]

Emtricitabine/tenofovir was approved for medical use in the United States in 2004.[5] It is on the World Health Organization's List of Essential Medicines.[9] In the United States, emtricitabine/tenofovir was under patent by Gilead until 2020, but is now available as a generic worldwide.[10] In 2020, it was the 278th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[11][12]

  1. ^ a b "Emtricitabine / tenofovir Pregnancy and Breastfeeding Warnings". Drugs.com. 1 August 2018. Archived from the original on 10 October 2019. Retrieved 10 October 2019.
  2. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  3. ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
  4. ^ "Truvada EPAR". European Medicines Agency. 21 February 2005. Retrieved 13 June 2024.
  5. ^ a b c d "Truvada". Drugs.com. Archived from the original on 20 December 2016. Retrieved 12 December 2016.
  6. ^ "UK label Truvada film-coated tablets". Electronic Medicines Compendium. August 2016. Archived from the original on 20 December 2016.
  7. ^ a b c d e Cite error: The named reference Truvada FDA label was invoked but never defined (see the help page).
  8. ^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 160. hdl:10665/44053. ISBN 9789241547659.
  9. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  10. ^ "AOC asks pharma CEO why $2,000 HIV drug costs just $8 in Australia". The Independent. 17 May 2019. Retrieved 15 November 2019.
  11. ^ "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
  12. ^ "Emtricitabine; Tenofovir Disoproxil - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.