Enaptin

SYNE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DXR
Identifiers
Aliases	SYNE1, 8B, ARCA1, C6orf98, CPG2, EDMD4, MYNE1, Nesp1, SCAR8, dJ45H2.2, spectrin repeat containing nuclear envelope protein 1, KASH1, AMCM, AMC3
External IDs	OMIM: 608441; MGI: 1927152; HomoloGene: 52329; GeneCards: SYNE1; OMA:SYNE1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.2 Start 152,121,687 bp[1] End 152,637,801 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 5,020,917 bp[2] End 5,551,482 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum Achilles tendon nucleus accumbens sural nerve left ovary right lung middle temporal gyrus caudate nucleus right frontal lobe Top expressed in cerebellar cortex lobe of cerebellum cerebellar vermis granulocyte habenula Region I of hippocampus proper superior frontal gyrus dentate gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function actin filament binding protein binding identical protein binding actin binding lamin binding protein homodimerization activity enzyme binding RNA binding Cellular component cytoplasm integral component of membrane postsynaptic membrane Golgi apparatus nuclear membrane nuclear envelope membrane sarcomere nucleoplasm meiotic nuclear membrane microtubule tethering complex nuclear outer membrane cytoskeleton nucleus P-body nucleolus Biological process nuclear matrix anchoring at nuclear membrane Golgi organization nucleus organization muscle cell differentiation spermatogenesis cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23345 64009 Ensembl ENSG00000131018 ENSMUSG00000096054 UniProt Q8NF91 Q6ZWR6 RefSeq (mRNA) NM_001099267 NM_001134379 NM_015293 NM_033071 NM_133650 NM_182961 NM_001347701 NM_001347702 NM_001079686 NM_022027 NM_153399 NM_001347711 NM_001347732 RefSeq (protein) NP_001334630 NP_001334631 NP_149062 NP_892006 NP_001073154 NP_001334640 NP_001334661 NP_071310 NP_700448 Location (UCSC) Chr 6: 152.12 – 152.64 Mb Chr 10: 5.02 – 5.55 Mb PubMed search [3] [4]
Wikidata
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Enaptin also known as nesprin-1 or synaptic nuclear envelope protein 1 (syne-1) is an actin-binding protein that in humans that is encoded by the SYNE1 gene.^[5]