 | This article needs to be updated. (January 2022) |
The Endothelium-derived relaxing factor (EDRF) is a strong vasodilator produced by cardiac endothelial cells in response to stress signals such as high levels of ADP accumulation or hypoxia.[1] Robert F. Furchgott is widely recognised for this discovery, even going so far as to be a co-recipient of the 1998 Nobel Prize in Medicine with his colleagues Louis J. Ignarro and Ferid Murad. Nitric oxide (NO) is a key component in any EDRF as these compounds either include NO or are structurally in the form of NO.[2][3]
- ^ "Endothelium Derived Relaxing Factor - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2023-01-21.
- ^ Bauer, Viktor; Sotníková, Ružena (29 December 2010). "Nitric oxide--the endothelium-derived relaxing factor and its role in endothelial functions". General Physiology and Biophysics. 29 (4): 319–340. doi:10.4149/gpb_2010_04_319. ISSN 0231-5882. PMID 21156995.
- ^ Francis, S. H.; Busch, J. L.; Corbin, J. D. (2010-09-01). "cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action". Pharmacological Reviews. 62 (3): 525–563. doi:10.1124/pr.110.002907. ISSN 0031-6997. PMC 2964902. PMID 20716671.