Enoxaparin sodium

Enoxaparin sodium
Clinical data
Trade namesLovenox, Clexane, Xaparin, others
BiosimilarsArovi, Axberi,[1] Axberi HP,[1] Exarane,[2] Exarane Forte,[2] Enoxapo,[3] Inclunox, Inclunox HP, Inhixa, Noromby, Noromby HP, Redesca, Redesca HP, Thorinane
AHFS/Drugs.comMonograph
MedlinePlusa696006
License data
Pregnancy
category
Routes of
administration		Subcutaneous, intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life4.5 hours
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
  • none
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.029.698 Edit this at Wikidata
Chemical and physical data
Formula(C26H40N2O36S5)n
Molar mass4500 g/mol (average)
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Enoxaparin sodium, sold under the brand name Lovenox among others, is an anticoagulant medication (blood thinner).[11] It is used to treat and prevent deep vein thrombosis (DVT) and pulmonary embolism (PE) including during pregnancy and following certain types of surgery.[11] It is also used in those with acute coronary syndrome (ACS) and heart attacks.[11] It is given by injection just under the skin or into a vein.[11] It is also used during hemodialysis.[8][10]

Common side effects include bleeding, fever, and swelling of the legs.[11] Bleeding may be serious especially in those who are undergoing a spinal tap.[11] Use during pregnancy appears to be safe for the baby.[11] Enoxaparin is in the low molecular weight heparin family of medications.[11]

Enoxaparin was first made in 1981 and approved for medical use in 1993.[12][11] It is on the World Health Organization's List of Essential Medicines.[13] Enoxaparin is sold under several brand names and is available as a generic medication.[11] Enoxaparin is made from heparin.[12] In 2020, it was the 350th most commonly prescribed medication in the United States, with more than 500 thousand prescriptions.[14]

  1. ^ a b "Summary Basis of Decision (SBD) for Axberi/Axberi HP". Health Canada. 26 January 2024. Archived from the original on 24 February 2024. Retrieved 24 February 2024.
  2. ^ a b c d "Exarane/Exarane Forte". Therapeutic Goods Administration (TGA). 7 August 2023. Archived from the original on 2 January 2024. Retrieved 4 July 2024.
  3. ^ a b c "Enoxapo Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). 28 February 2020. Archived from the original on 26 February 2020. Retrieved 17 August 2020.
  4. ^ "Enoxaparin Use During Pregnancy". Drugs.com. 15 July 2019. Archived from the original on 27 October 2020. Retrieved 16 August 2020.
  5. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  6. ^ "AusPAR: Exarane/Exarane Forte". Therapeutic Goods Administration (TGA). 4 March 2024. Archived from the original on 31 March 2024. Retrieved 31 March 2024.
  7. ^ "Summary Basis of Decision - Elonox/Elonox HP". Health Canada. 28 March 2023. Archived from the original on 25 April 2023. Retrieved 24 April 2023.
  8. ^ a b "Clexane Forte Syringes - Summary of Product Characteristics (SmPC)". emc. Archived from the original on 26 September 2018. Retrieved 12 October 2020.
  9. ^ "Lovenox- enoxaparin sodium injection". DailyMed. U.S. National Library of Medicine. 28 April 2020. Archived from the original on 4 August 2020. Retrieved 16 August 2020.
  10. ^ a b Cite error: The named reference Inhixa EPAR was invoked but never defined (see the help page).
  11. ^ a b c d e f g h i j "Enoxaparin Sodium". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
  12. ^ a b Northern Neonatal Network (2008). "Enoxaparin". Neonatal Formulary: Drug Use in Pregnancy and the First Year of Life. John Wiley & Sons. p. 96. ISBN 9780470750353. Archived from the original on 20 December 2016.
  13. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  14. ^ "Enoxaparin - Drug Usage Statistics". ClinCalc. Archived from the original on 7 November 2022. Retrieved 7 October 2022.