Envoplakin

EVPL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4QMD
Identifiers
Aliases	EVPL, EVPK, envoplakin
External IDs	OMIM: 601590; MGI: 107507; HomoloGene: 1506; GeneCards: EVPL; OMA:EVPL - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,027,306 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,128,903 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; mucosa of pharynx; ; skin of arm; ; gums; ; oral cavity; ; gingival epithelium; ; skin of thigh; ; epithelium of esophagus; ; nipple;
	Top expressed in
	esophagus; ; lip; ; epidermis; ; hair follicle; ; transitional epithelium of urinary bladder; ; skin of external ear; ; skin of abdomen; ; skin of back; ; conjunctival fornix; ; cornea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; intermediate filament binding; structural molecule activity; cadherin binding;
Cellular component	cell junction; desmosome; intermediate filament cytoskeleton; extracellular exosome; cytoskeleton; cornified envelope; cytoplasm; cytosol; intermediate filament; membrane;
Biological process	peptide cross-linking; keratinization; keratinocyte differentiation; epidermis development; cornification; wound healing; intermediate filament cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	2125
	14027
	ENSG00000167880
	ENSMUSG00000034282
	Q92817
	Q9D952
	NM_001988; NM_001320747
	NM_025276
	NP_001307676; NP_001979; NP_001307676.1
	NP_079552
	Wikidata
View/Edit Human	View/Edit Mouse

Envoplakin is a protein that in humans is encoded by the EVPL gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167880 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034282 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ruhrberg C, Williamson JA, Sheer D, Watt FM (Mar 1997). "Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25". Genomics. 37 (3): 381–5. doi:10.1006/geno.1996.0573. PMID 8938451.
^ Risk JM, Ruhrberg C, Hennies H, Mills HS, Di Colandrea T, Evans KE, Ellis A, Watt FM, Bishop DT, Spurr NK, Stevens HP, Leigh IM, Reis A, Kelsell DP, Field JK (Sep 1999). "Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25". Genomics. 59 (2): 234–42. doi:10.1006/geno.1999.5857. PMID 10409435.
^ "Entrez Gene: EVPL envoplakin".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167880 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034282 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8938451-5] Ruhrberg C, Williamson JA, Sheer D, Watt FM (Mar 1997). "Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25". Genomics. 37 (3): 381–5. doi:10.1006/geno.1996.0573. PMID 8938451.

[pmid10409435-6] Risk JM, Ruhrberg C, Hennies H, Mills HS, Di Colandrea T, Evans KE, Ellis A, Watt FM, Bishop DT, Spurr NK, Stevens HP, Leigh IM, Reis A, Kelsell DP, Field JK (Sep 1999). "Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25". Genomics. 59 (2): 234–42. doi:10.1006/geno.1999.5857. PMID 10409435.

[entrez-7] "Entrez Gene: EVPL envoplakin".

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