| Eosinophilic cellulitis | |
|---|---|
| Other names | Wells' syndrome, recurrent granulomatous dermatitis with eosinophilia[1] |
 | |
| Initial rash in eosinophilic cellulitis | |
| Specialty | Dermatology |
| Symptoms | Painful, red, raised, warm patches of skin, fever, joint pain[2] |
| Usual onset | Sudden and recurrent[2] |
| Duration | Few weeks[2] |
| Causes | Unknown[2] |
| Differential diagnosis | Vasculitis, cellulitis, anaphylaxis[2][1] |
| Medication | Corticosteroids, antihistamines[2][1] |
| Prognosis | Often goes away by itself[2] |
| Frequency | ~200 documented cases[1] |
Eosinophilic cellulitis, also known as Wells' syndrome (not to be confused with Weil's disease), is a skin disease that presents with painful, red, raised, and warm patches of skin.[2] The rash comes on suddenly, lasts for a few weeks, and often repeatedly comes back.[2] Scar formation does not typically occur.[1]
Eosinophilic cellulitis is of unknown cause.[2] It is suspected to be an autoimmune disorder.[2] It may be triggered by bites from insects and arachnids such as spiders, fleas, or ticks, or from medications or surgery.[2] Diagnosis is made after other potential cases are ruled out.[1] Skin biopsy of the affected areas may show an increased number of eosinophils.[2] Other conditions that may appear similar include cellulitis, contact dermatitis, and severe allergic reactions such as anaphylaxis.[2]
Treatment is often with a corticosteroids.[2] Steroids applied as a cream is generally recommended over the use of steroids by mouth.[3] Antihistamines may be used to help with itchiness.[1] Many times the condition goes away after a few weeks without treatment.[2] The condition is uncommon.[1] It affects both sexes with the same frequency.[2] It was first described by George Crichton Wells in 1971.[1][4]
- ^ a b c d e f g h i Weins, AB; Biedermann, T; Weiss, T; Weiss, JM (October 2016). "Wells syndrome". Journal der Deutschen Dermatologischen Gesellschaft. 14 (10): 989–993. doi:10.1111/ddg.13132. PMID 27767278.
- ^ a b c d e f g h i j k l m n o p q "Familial Eosinophilic Cellulitis - NORD (National Organization for Rare Disorders)". NORD (National Organization for Rare Disorders). 2009. Retrieved 10 April 2017.
- ^ Cite error: The named reference
Ra2016was invoked but never defined (see the help page). - ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.