Epigen

EPGN
Identifiers
Aliases	EPGN, ALGV3072, EPG, PRO9904, epithelial mitogen
External IDs	MGI: 1919170; HomoloGene: 19527; GeneCards: EPGN; OMA:EPGN - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	74,316,789 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	91,183,074 bp
RNA expression pattern
	Top expressed in
	mucosa of esophagus; ; vagina; ; skin of leg; ; appendix; ; skin of abdomen; ; right lung; ; tonsil; ; bone marrow cells; ; ectocervix; ; mucosa of transverse colon;
	Top expressed in
	embryo; ; cornea; ; embryo; ; hair follicle; ; spermatid; ; lip; ; skin of abdomen; ; conjunctival fornix; ; skin of back; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	epidermal growth factor receptor binding; growth factor activity;
Cellular component	integral component of membrane; extracellular region; integral component of plasma membrane; intracellular anatomical structure; membrane; extracellular space; clathrin-coated vesicle membrane;
Biological process	positive regulation of epidermal growth factor-activated receptor activity; positive regulation of mitotic nuclear division; positive regulation of MAP kinase activity; angiogenesis; positive regulation of cell population proliferation; MAPK cascade; positive regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; signal transduction; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	255324
	71920
	ENSG00000182585
	ENSMUSG00000035020
	Q6UW88
	Q924X1
NM_001013442; NM_001270989; NM_001270990; NM_001270991; NM_001270992;
	NM_001270993
	NM_053087
	NP_001257918; NP_001257919; NP_001257920; NP_001257921; NP_001257922
	NP_444317
	Wikidata
View/Edit Human	View/Edit Mouse

Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182585 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035020 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Epithelial mitogen".
^ Schneider MR, Yarden Y (2014). "Structure and function of epigen, the last EGFR ligand". Semin. Cell Dev. Biol. 28: 57–61. doi:10.1016/j.semcdb.2013.12.011. PMC 4037347. PMID 24374012.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182585 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035020 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Epithelial mitogen".

[pmid24374012-6] Schneider MR, Yarden Y (2014). "Structure and function of epigen, the last EGFR ligand". Semin. Cell Dev. Biol. 28: 57–61. doi:10.1016/j.semcdb.2013.12.011. PMC 4037347. PMID 24374012.

[1]

[2]

[3]

[4]

[5]

[6]