Epiregulin

EREG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K36, 1K37, 5E8D
Identifiers
Aliases	EREG, EPR, ER, Ep, epiregulin
External IDs	OMIM: 602061; MGI: 107508; HomoloGene: 1097; GeneCards: EREG; OMA:EREG - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	74,388,749 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	91,241,505 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; amniotic fluid; ; skin of thigh; ; skin of arm; ; human penis; ; cervix epithelium; ; oral cavity; ; bone marrow cells; ; skin of abdomen; ; gums;
	Top expressed in
	skin of external ear; ; conjunctival fornix; ; esophagus; ; umbilical cord; ; endothelial cell of lymphatic vessel; ; tunica media of zone of aorta; ; skin of back; ; ileum; ; cornea; ; epidermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	epidermal growth factor receptor binding; protein binding; growth factor activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; intracellular anatomical structure; extracellular space; clathrin-coated vesicle membrane;
Biological process	luteinizing hormone signaling pathway; positive regulation of epidermal growth factor-activated receptor activity; cell differentiation; ovarian cumulus expansion; negative regulation of smooth muscle cell differentiation; positive regulation of cytokine production; cytokine-mediated signaling pathway; positive regulation of fibroblast proliferation; cell-cell signaling; anatomical structure morphogenesis; response to peptide hormone; wound healing; mRNA transcription; female meiotic nuclear division; primary follicle stage; keratinocyte differentiation; MAPK cascade; multicellular organism development; positive regulation of DNA replication; keratinocyte proliferation; oocyte maturation; angiogenesis; positive regulation of cell population proliferation; positive regulation of innate immune response; negative regulation of epithelial cell proliferation; animal organ morphogenesis; positive regulation of phosphorylation; negative regulation of transcription, DNA-templated; positive regulation of mitotic nuclear division; ovulation; positive regulation of cell division; negative regulation of cell population proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of protein kinase activity; ERBB2 signaling pathway; regulation of cell motility; epidermal growth factor receptor signaling pathway; peptidyl-tyrosine phosphorylation; phosphatidylinositol phosphate biosynthetic process; positive regulation of protein kinase B signaling; signal transduction; negative regulation of epidermal growth factor receptor signaling pathway; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	2069
	13874
	ENSG00000124882
	ENSMUSG00000029377
	O14944
	Q61521
	NM_001432
	NM_007950
	NP_001423
	NP_031976
	Wikidata
View/Edit Human	View/Edit Mouse

Epiregulin (EPR) is a protein that in humans is encoded by the EREG gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124882 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029377 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Toyoda H, Komurasaki T, Uchida D, Morimoto S (August 1997). "Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family". Biochem. J. 326 (1): 69–75. doi:10.1042/bj3260069. PMC 1218638. PMID 9337852.
^ "Entrez Gene: epiregulin".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124882 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029377 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9337852-5] Toyoda H, Komurasaki T, Uchida D, Morimoto S (August 1997). "Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family". Biochem. J. 326 (1): 69–75. doi:10.1042/bj3260069. PMC 1218638. PMID 9337852.

[entrez-6] "Entrez Gene: epiregulin".

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