Eprosartan

Eprosartan
Clinical data
Trade names	Teveten
AHFS/Drugs.com	Monograph
MedlinePlus	a601237
License data	US DailyMed: Eprosartan;
Pregnancy; category	AU: D; ;
Routes of; administration	By mouth
ATC code	C09CA02 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	15% (Eprosartan mesylate)
Metabolism	not metabolized
Elimination half-life	5 to 9 hours
Excretion	Kidney 10%, bile duct 90%
Identifiers
	IUPAC name 4-({2-Butyl-5-[2-carboxy-2-(thiophen-2-ylmethyl)eth-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid;
CAS Number	133040-01-4 ;
PubChem CID	5281037;
IUPHAR/BPS	588;
DrugBank	DB00876 ;
ChemSpider	4444504 ;
UNII	2KH13Z0S0Y;
KEGG	D04040 ; as mesylate: D02082 ;
ChEBI	CHEBI:4814 ;
ChEMBL	ChEMBL813 ;
CompTox Dashboard (EPA)	DTXSID0022989 ;
Chemical and physical data
Formula	C23H24N2O4S
Molar mass	424.52 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)\C(=C\c1cnc(n1Cc2ccc(C(=O)O)cc2)CCCC)Cc3sccc3;
	InChI InChI=1S/C23H24N2O4S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29)/b18-12+ ; Key:OROAFUQRIXKEMV-LDADJPATSA-N ;
	(verify)

Eprosartan, sold under the brand name Teveten among others, is an angiotensin II receptor antagonist used for the treatment of high blood pressure.^[1]

Eprosartan is sometimes paired with hydrochlorothiazide.^[2]

As with other angiotensin II receptor antagonists, eprosartan is generally better tolerated than enalapril (an ACE inhibitor), especially among the elderly.^[3]

^ "Eprosartan mesylate- eprosartan mesylate tablet, film coated". DailyMed. Retrieved 7 June 2023.
^ "Teveten HCT- eprosartan mesylate and hydrochlorothiazide tablet". DailyMed. 3 January 2012. Retrieved 7 June 2023.
^ Ruilope L, Jäger B, Prichard B (2001). "Eprosartan versus enalapril in elderly patients with hypertension: a double-blind, randomized trial". Blood Press. 10 (4): 223–9. doi:10.1080/08037050152669747. PMID 11800061. S2CID 13063704.

[1] "Eprosartan mesylate- eprosartan mesylate tablet, film coated". DailyMed. Retrieved 7 June 2023.

[2] "Teveten HCT- eprosartan mesylate and hydrochlorothiazide tablet". DailyMed. 3 January 2012. Retrieved 7 June 2023.

[3] Ruilope L, Jäger B, Prichard B (2001). "Eprosartan versus enalapril in elderly patients with hypertension: a double-blind, randomized trial". Blood Press. 10 (4): 223–9. doi:10.1080/08037050152669747. PMID 11800061. S2CID 13063704.

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