Erbin (protein)

ERBIN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MFG, 1MFL, 1N7T, 2H3L, 2QBW, 3CH8
Identifiers
Aliases	ERBIN, HEL-S-78, LAP2, ERBB2IP, erbb2 interacting protein
External IDs	OMIM: 606944; MGI: 1890169; HomoloGene: 41282; GeneCards: ERBIN; OMA:ERBIN - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	66,082,546 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	104,057,022 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; external globus pallidus; ; optic nerve; ; subthalamic nucleus; ; internal globus pallidus; ; inferior ganglion of vagus nerve; ; pars reticulata; ; medulla oblongata; ; mucosa of paranasal sinus; ; superior vestibular nucleus;
	Top expressed in
	parotid gland; ; submandibular gland; ; left lung lobe; ; left colon; ; conjunctival fornix; ; epithelium of small intestine; ; lacrimal gland; ; seminal vesicula; ; Gonadal ridge; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of cytoskeleton; ErbB-2 class receptor binding; protein binding; signaling receptor binding;
Cellular component	cytoplasm; nuclear membrane; membrane; plasma membrane; hemidesmosome; basement membrane; cell junction; basal plasma membrane; basolateral plasma membrane; nucleus; nuclear speck; neuromuscular junction; postsynapse; glutamatergic synapse; postsynaptic specialization;
Biological process	negative regulation of monocyte chemotactic protein-1 production; protein targeting; epidermal growth factor receptor signaling pathway; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; cellular response to tumor necrosis factor; response to muramyl dipeptide; basal protein localization; cell growth; response to lipopolysaccharide; cell adhesion; establishment or maintenance of epithelial cell apical/basal polarity; intermediate filament cytoskeleton organization; integrin-mediated signaling pathway; negative regulation of NF-kappaB transcription factor activity; signal transduction; ERBB2 signaling pathway; regulation of postsynaptic membrane neurotransmitter receptor levels;
	Sources:Amigo / QuickGO
Orthologs
	55914
	59079
	ENSG00000112851
	ENSMUSG00000021709
	Q96RT1
	Q80TH2
NM_001006600; NM_001253697; NM_001253698; NM_001253699; NM_001253701;
	NM_018695
	NM_001005868; NM_021563; NM_001289473; NM_001289474; NM_001289475
NP_001006600; NP_001240626; NP_001240627; NP_001240628; NP_001240630;
	NP_061165
	NP_001005868; NP_001276402; NP_001276403; NP_001276404
	Wikidata
View/Edit Human	View/Edit Mouse

Erbb2 interacting protein (ERBB2IP), also known as erbin, is a protein which in humans is encoded by the ERBB2IP gene.^[5] Discovered in 1997, erbin is a 200kDa protein containing a PDZ domain.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112851 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021709 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ERBB2IP erbb2 interacting protein".
^ Borg JP, Marchetto S, Le Bivic A, Ollendorff V, Jaulin-Bastard F, Saito H, Fournier E, Adélaïde J, Margolis B, Birnbaum D (2000). "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor" (PDF). Nat. Cell Biol. 2 (7): 407–414. doi:10.1038/35017038. PMID 10878805. S2CID 9566913.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112851 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021709 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ERBB2IP erbb2 interacting protein".

[6] Borg JP, Marchetto S, Le Bivic A, Ollendorff V, Jaulin-Bastard F, Saito H, Fournier E, Adélaïde J, Margolis B, Birnbaum D (2000). "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor" (PDF). Nat. Cell Biol. 2 (7): 407–414. doi:10.1038/35017038. PMID 10878805. S2CID 9566913.

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