Escargot (transcription factor)

Escargot
Identifiers
OrganismDrosophila melanogaster
SymbolDmel/esg
UniProtP25932
Search for
StructuresSwiss-model
DomainsInterPro

Escargot (esg) is a transcription factor expressed in Drosophila melanogaster. It is responsible for the maintenance of intestinal stem cells and is used as a marker for those types of cells in Drosophila.[1][2][3] Apart from its expression in the gut, esg is also expressed in expressed in germline stem cells and cyst stem cells of the testis[4][5] and, during development, in neural stem cells and imaginal disks.[6][7][8]

  1. ^ Whiteley, Mary; Noguchi, Philip D.; Sensabaugh, Suzanne M.; Odenwald, Ward F.; Kassis, Judith A. (1992-02-01). "The Drosophila gene escargot encodes a zinc finger motif found in snail-related genes". Mechanisms of Development. 36 (3): 117–127. doi:10.1016/0925-4773(92)90063-P. ISSN 0925-4773. PMID 1571289. S2CID 23873732.
  2. ^ Korzelius, Jerome; Naumann, Svenja K; Loza-Coll, Mariano A; Chan, Jessica SK; Dutta, Devanjali; Oberheim, Jessica; Gläßer, Christine; Southall, Tony D; Brand, Andrea H; Jones, D Leanne; Edgar, Bruce A (2014-10-08). "Escargotmaintains stemness and suppresses differentiation inDrosophilaintestinal stem cells". The EMBO Journal. 33 (24): 2967–2982. doi:10.15252/embj.201489072. ISSN 0261-4189. PMC 4282643. PMID 25298397. S2CID 1335408.
  3. ^ Loza-Coll, Mariano A; Southall, Tony D; Sandall, Sharsti L; Brand, Andrea H; Jones, D Leanne (2014-12-17). "Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot". EMBO Journal. 33 (24): 2983–2996. doi:10.15252/embj.201489050. ISSN 0261-4189. PMC 4282644. PMID 25433031.
  4. ^ Kiger, Amy A.; White-Cooper, Helen; Fuller, Margaret T. (2000-10-12). "Somatic support cells restrict germline stem cell self-renewal and promote differentiation". Nature. 407 (6805): 750–754. Bibcode:2000Natur.407..750K. doi:10.1038/35037606. ISSN 1476-4687. PMID 11048722. S2CID 4349276.
  5. ^ Voog, Justin; Sandall, Sharsti L.; Hime, Gary R.; Resende, Luís Pedro F.; Loza-Coll, Mariano; Aslanian, Aaron; Yates, John R.; Hunter, Tony; Fuller, Margaret T.; Jones, D. Leanne (2014-05-08). "Escargot Restricts Niche Cell to Stem Cell Conversion in the Drosophila Testis". Cell Reports. 7 (3): 722–734. doi:10.1016/j.celrep.2014.04.025. ISSN 2211-1247. PMC 4128242. PMID 24794442.
  6. ^ Hayashi, Shigeo; Hirose, Susumu; Metcalfe, Tony; Shirras, Alan D. (1993-05-01). "Control of imaginal cell development by the escargot gene of Drosophila". Development. 118 (1): 105–115. doi:10.1242/dev.118.1.105. ISSN 0950-1991. PMID 8375329.
  7. ^ Ashraf, Shovon I.; Hu, Xiaodi; Roote, John; Ip, Y. Tony (1999-11-15). "The mesoderm determinant Snail collaborates with related zinc-finger proteins to control Drosophila neurogenesis". The EMBO Journal. 18 (22): 6426–6438. doi:10.1093/emboj/18.22.6426. ISSN 0261-4189. PMC 1171705. PMID 10562554.
  8. ^ Cai, Y. (2001-04-02). "A family of Snail-related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions". The EMBO Journal. 20 (7): 1704–1714. doi:10.1093/emboj/20.7.1704. PMC 145473. PMID 11285234.