Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3 (nuclear receptor subfamily 3, group B, member 3), is a nuclear receptor that in humans is encoded by the ESRRG (EStrogen Related Receptor Gamma) gene.[5][6][7] It behaves as a constitutive activator of transcription.[8]
This protein is a member of nuclear hormone receptor family of steroid hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.[9] It also seems to be the target of bisphenol A (see below).
- ^ a b c GRCh38: Ensembl release 89: ENSG00000196482 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026610 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: ESRRG estrogen-related receptor gamma".
- ^ Eudy JD, Yao S, Weston MD, Ma-Edmonds M, Talmadge CB, Cheng JJ, Kimberling WJ, Sumegi J (Jun 1998). "Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41". Genomics. 50 (3): 382–4. doi:10.1006/geno.1998.5345. PMID 9676434.
- ^ Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT (Mar 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–9. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763.
- ^ Cite error: The named reference
matsushimawas invoked but never defined (see the help page). - ^ Huppunen J, Aarnisalo P (Feb 2004). "Dimerization modulates the activity of the orphan nuclear receptor ERRgamma". Biochemical and Biophysical Research Communications. 314 (4): 964–70. doi:10.1016/j.bbrc.2003.12.194. PMID 14751226.