Estrogen receptor alpha

ESR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A52, 1ERE, 1ERR, 1G50, 1GWQ, 1GWR, 1HCP, 1HCQ, 1L2I, 1PCG, 1QKT, 1QKU, 1R5K, 1SJ0, 1UOM, 1X7E, 1X7R, 1XP1, 1XP6, 1XP9, 1XPC, 1XQC, 1YIM, 1YIN, 1ZKY, 2AYR, 2B1V, 2B1Z, 2B23, 2BJ4, 2FAI, 2G44, 2G5O, 2I0J, 2IOG, 2IOK, 2JF9, 2JFA, 2LLO, 2LLQ, 2OCF, 2OUZ, 2P15, 2POG, 2Q6J, 2Q70, 2QA6, 2QA8, 2QAB, 2QE4, 2QGT, 2QGW, 2QH6, 2QR9, 2QSE, 2QXM, 2QXS, 2QZO, 2R6W, 2R6Y, 2YAT, 2YJA, 3CBM, 3CBO, 3CBP, 3DT3, 3ERD, 3ERT, 3HLV, 3HM1, 3L03, 3OS8, 3OS9, 3OSA, 3Q95, 3Q97, 3UU7, 3UUA, 3UUC, 3UUD, 4AA6, 4DMA, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 4JC3, 4JDD, 4MG5, 4MG6, 4MG7, 4MG8, 4MG9, 4MGA, 4MGB, 4MGC, 4MGD, 4O6F, 4PP6, 4PPP, 4PPS, 4PXM, 4Q13, 4Q50, 4TUZ, 4TV1, 5AK2, 5AAV, 5ACC, 5AAU, 4XI3, 4ZN9, 5FQS, 5FQR, 5FQP, 5FQT, 5FQV, 4ZN7, 5E0W, 5DUG, 4ZUC, 5DXK, 5E19, 5DXQ, 5EI1, 5DXR, 5DVS, 5DZ1, 5E0X, 5DKB, 5DWI, 5E14, 5DXB, 5BPR, 5EIT, 5E15, 4ZNS, 5EGV, 5DL4, 5DWE, 4ZNT, 5EHJ, 5DYD, 5DWG, 4ZNV, 5DWJ, 5DID, 4ZUB, 5BNU, 5DMC, 5DK9, 5DIG, 5DUH, 5DKS, 5DMF, 5DU5, 5DY8, 4ZWH, 5DVV, 5DLR, 4ZWK, 5DRM, 5DP0, 5DKE, 5DZI, 5DZ3, 4ZNU, 5DIE, 5DZ0, 5E1C, 5HYR, 5BQ4, 4ZNW, 5DUE, 5DTV, 5DRJ, 5DKG, 4ZNH, 5BP6, 5DXG, 5DI7, 5DX3, 5DYB, 5DXP, 5DZH, 5DXM
Identifiers
Aliases	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1, estrogen receptor 1
External IDs	OMIM: 133430; MGI: 1352467; HomoloGene: 47906; GeneCards: ESR1; OMA:ESR1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	152,129,619 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	4,955,614 bp
RNA expression pattern
	Top expressed in
	cervix epithelium; ; vulva; ; endometrium; ; canal of the cervix; ; right uterine tube; ; ectocervix; ; epithelium of lactiferous gland; ; lactiferous duct; ; body of uterus; ; vagina;
	Top expressed in
	gastrula; ; vas deferens; ; efferent ductule; ; uterus; ; decidua; ; intercostal muscle; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; lumbar spinal ganglion; ; temporal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; nitric-oxide synthase regulator activity; nuclear receptor activity; estrogen response element binding; transcription factor binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; steroid hormone receptor activity; steroid binding; beta-catenin binding; zinc ion binding; chromatin binding; protein binding; DNA binding; sequence-specific DNA binding; ATPase binding; identical protein binding; lipid binding; core promoter sequence-specific DNA binding; enzyme binding; protein kinase binding; TFIIB-class transcription factor binding; TBP-class protein binding; estrogen receptor activity; estrogen receptor binding; transcription coactivator binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; membrane; nucleus; integral component of membrane; Golgi apparatus; plasma membrane; nucleoplasm; transcription preinitiation complex; cytosol; protein-containing complex;
Biological process	epithelial cell development; positive regulation of phospholipase C activity; mammary gland alveolus development; transcription by RNA polymerase II; phospholipase C-activating G protein-coupled receptor signaling pathway; epithelial cell proliferation involved in mammary gland duct elongation; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; protein localization to chromatin; steroid hormone mediated signaling pathway; regulation of apoptotic process; chromatin remodeling; regulation of transcription, DNA-templated; androgen metabolic process; positive regulation of fibroblast proliferation; mammary gland branching involved in pregnancy; negative regulation of gene expression; transcription, DNA-templated; negative regulation of DNA-binding transcription factor activity; cellular response to estrogen stimulus; positive regulation of transcription, DNA-templated; positive regulation of nitric-oxide synthase activity; transcription initiation from RNA polymerase II promoter; regulation of branching involved in prostate gland morphogenesis; male gonad development; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of production of miRNAs involved in gene silencing by miRNA; response to estrogen; uterus development; prostate epithelial cord elongation; antral ovarian follicle growth; vagina development; positive regulation of cytosolic calcium ion concentration; positive regulation of nitric oxide biosynthetic process; signal transduction; positive regulation of transcription by RNA polymerase II; intracellular steroid hormone receptor signaling pathway; regulation of inflammatory response; response to estradiol; regulation of toll-like receptor signaling pathway; regulation of transcription by RNA polymerase II; protein deubiquitination; cellular response to estradiol stimulus; intracellular estrogen receptor signaling pathway; positive regulation of RNA polymerase II transcription preinitiation complex assembly; stem cell differentiation; regulation of Wnt signaling pathway; regulation of intracellular estrogen receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	2099
	13982
	ENSG00000091831
	ENSMUSG00000019768
	P03372
	P19785
NM_000125; NM_001122740; NM_001122741; NM_001122742; NM_001291230;
	NM_001291241; NM_001328100; NM_001385568; NM_001385569; NM_001385570; NM_001385571; NM_001385572
	NM_007956; NM_001302531; NM_001302532; NM_001302533
NP_000116; NP_001116212; NP_001116213; NP_001116214; NP_001278159;
	NP_001278170; NP_001315029
	NP_001289460; NP_001289461; NP_001289462; NP_031982
	Wikidata
View/Edit Human	View/Edit Mouse

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding protein^[5]) that is activated by the sex hormone estrogen. In humans, ERα is encoded by the gene ESR1 (EStrogen Receptor 1).^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000091831 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019768 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dhamad AE, Zhou Z, Zhou J, Du Y (2016-08-02). Picard D (ed.). "Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction". PLOS ONE. 11 (8): e0160312. Bibcode:2016PLoSO..1160312D. doi:10.1371/journal.pone.0160312. PMC 4970746. PMID 27483141.
^ "Entrez Gene: ESR1 estrogen receptor 1".
^ Walter P, Green S, Greene G, Krust A, Bornert JM, Jeltsch JM, et al. (December 1985). "Cloning of the human estrogen receptor cDNA". Proceedings of the National Academy of Sciences of the United States of America. 82 (23): 7889–7893. Bibcode:1985PNAS...82.7889W. doi:10.1073/pnas.82.23.7889. PMC 390875. PMID 3865204.
^ Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J (March 1986). "Sequence and expression of human estrogen receptor complementary DNA". Science. 231 (4742): 1150–1154. Bibcode:1986Sci...231.1150G. doi:10.1126/science.3753802. PMID 3753802.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091831 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019768 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Dhamad AE, Zhou Z, Zhou J, Du Y (2016-08-02). Picard D (ed.). "Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction". PLOS ONE. 11 (8): e0160312. Bibcode:2016PLoSO..1160312D. doi:10.1371/journal.pone.0160312. PMC 4970746. PMID 27483141.

[entrez-6] "Entrez Gene: ESR1 estrogen receptor 1".

[pmid3865204-7] Walter P, Green S, Greene G, Krust A, Bornert JM, Jeltsch JM, et al. (December 1985). "Cloning of the human estrogen receptor cDNA". Proceedings of the National Academy of Sciences of the United States of America. 82 (23): 7889–7893. Bibcode:1985PNAS...82.7889W. doi:10.1073/pnas.82.23.7889. PMC 390875. PMID 3865204.

[pmid3753802-8] Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J (March 1986). "Sequence and expression of human estrogen receptor complementary DNA". Science. 231 (4742): 1150–1154. Bibcode:1986Sci...231.1150G. doi:10.1126/science.3753802. PMID 3753802.

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