Etacrynic acid

Etacrynic acid
Clinical data
Trade names	Edecrin
AHFS/Drugs.com	International Drug Names
MedlinePlus	a682857
Routes of; administration	Oral, IV
ATC code	C03CC01 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	> 98%
Identifiers
	IUPAC name [2,3-dichloro-4-(2-methylenebutanoyl)phenoxy]acetic acid;
CAS Number	58-54-8 ;
PubChem CID	3278;
IUPHAR/BPS	7179;
DrugBank	DB00903 ;
ChemSpider	3163 ;
UNII	M5DP350VZV;
KEGG	D00313 ;
ChEBI	CHEBI:4876 ;
ChEMBL	ChEMBL456 ;
CompTox Dashboard (EPA)	DTXSID3025257 ;
ECHA InfoCard	100.000.349
Chemical and physical data
Formula	C13H12Cl2O4
Molar mass	303.14 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)COc1c(Cl)c(Cl)c(cc1)C(=O)C(=C)CC;
	InChI InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17) ; Key:AVOLMBLBETYQHX-UHFFFAOYSA-N ;
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Etacrynic acid (INN) or ethacrynic acid (USAN), trade name Edecrin, is a loop diuretic used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure. A con with ethacrynic acid compared to the other loop diuretic drugs such as furosemide is that it has a significantly steep dose-response curve, which means the drug's dosing is very important as small variance in dose can cause a significant difference in the biological response.

Unlike the other loop diuretics, etacrynic acid is not a sulfonamide^[1] and may thus be used in individuals with sulfa allergies in whom the sulfonamide loop diuretics would be contraindicated.

^ Somberg JC, Molnar J (January 2009). "The pleiotropic effects of ethacrynic acid". American Journal of Therapeutics. 16 (1): 102–4. doi:10.1097/MJT.0b013e3181961264. PMID 19142157.

[pmid19142157-1] Somberg JC, Molnar J (January 2009). "The pleiotropic effects of ethacrynic acid". American Journal of Therapeutics. 16 (1): 102–4. doi:10.1097/MJT.0b013e3181961264. PMID 19142157.

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