Ethinylestradiol/levonorgestrel

"Alysena" redirects here. For the moth genus, see Alysina. For the surname, see Ali Sina.
For the Twirla contraceptive patch, see Contraceptive patch.

Ethinylestradiol/levonorgestrel
Combination of
EthinylestradiolEstrogen
LevonorgestrelProgestogen
Clinical data
Trade namesAltavera, Alysena, Amethyst, others[1]
Other namesEE/LNG
AHFS/Drugs.comMonograph
MedlinePlusa601050
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG
Rigevidon, an example of a combined ethinylestradiol/levonorgestrel contraceptive pill

Ethinylestradiol/levonorgestrel (EE/LNG) is a combined birth control pill made up of ethinylestradiol, an estrogen and levonorgestrel a progestin.[3] It is used for birth control, symptoms of menstruation, endometriosis, and as emergency contraception.[1][3] It is taken by mouth.[1] Some preparations of EE/LNG additionally contain an iron supplement in the form of ferrous bisglycinate or ferrous fumarate.[4]

Side effects can include nausea, headache, blood clots, breast pain, depression, and liver problems.[3] Use is not recommended during pregnancy, the initial three weeks after childbirth, and in those at high risk of blood clots.[3] However, it may be started immediately after a miscarriage or abortion.[5] Smoking while using combined birth control pills is not recommended.[1] It works by stopping ovulation, making the mucus at the opening to the cervix thick, and making the uterus not suitable for implantation.[1]

Ethinylestradiol/levonorgestrel has been approved for medical use in the United States since 1982.[1] It is on the World Health Organization's List of Essential Medicines.[6] It is available as a generic medication.[7] It is marketed under many brand names.[1] In 2022, it was the 128th most commonly prescribed medication in the United States, with more than 4 million prescriptions.[8][9]

  1. ^ a b c d e f g "Ethinyl estradiol and levonorgestrel medical facts from Drugs.com". www.drugs.com. Archived from the original on 1 January 2017. Retrieved 1 January 2017.
  2. ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
  3. ^ a b c d World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 363–5. hdl:10665/44053. ISBN 9789241547659.
  4. ^ Hamilton, RJ, ed. (April 2020). Tarascon Pocket Pharmacopoeia 2020 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. pp. 347–. ISBN 978-1-284-40304-6.
  5. ^ "Erlibelle 30micrograms/150micrograms film-coated tablets - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. Archived from the original on 2 January 2017. Retrieved 1 January 2017.
  6. ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  7. ^ Hamilton, RJ, ed. (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 349. ISBN 9781284057560.
  8. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  9. ^ "Ethinyl Estradiol; Levonorgestrel Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.