Etomidate

Etomidate
(R)-etomidate
Clinical data
Trade namesAmidate, Hypnomidate, Tomvi
AHFS/Drugs.comMonograph
License data
Routes of
administration
Intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding76%
MetabolismEster hydrolysis in plasma and liver
Elimination half-life75 minutes
ExcretionUrine (85%) and Bile duct (15%)
Identifiers
  • Ethyl 3-[(1R)-1-phenylethyl]imidazole-5-carboxylate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.046.700 Edit this at Wikidata
Chemical and physical data
FormulaC14H16N2O2
Molar mass244.294 g·mol−1
3D model (JSmol)
Melting point67 °C (153 °F)
Boiling point392 °C (738 °F)
  • O=C(OCC)c1cncn1C(c2ccccc2)C
  • InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3 checkY
  • Key:NPUKDXXFDDZOKR-UHFFFAOYSA-N checkY
  (verify)

Etomidate[3] (USAN, INN, BAN; marketed as Amidate) is a short-acting intravenous anaesthetic agent used for the induction of general anaesthesia and sedation[4] for short procedures such as reduction of dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy. It was developed at Janssen Pharmaceutica in 1964 and was introduced as an intravenous agent in 1972 in Europe and in 1983 in the United States.[5]

The most common side effects include venous pain on injection and skeletal muscle movements.[6]

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ "Summary Basis of Decision (SBD) for Tomvi". Health Canada. 23 October 2014. Retrieved 29 May 2022.
  3. ^ US Patent 3354173 'Imidazole carboxylates'
  4. ^ Vinson DR, Bradbury DR (June 2002). "Etomidate for procedural sedation in emergency medicine". Annals of Emergency Medicine. 39 (6): 592–598. doi:10.1067/mem.2002.123695. PMID 12023700.
  5. ^ Bergen JM, Smith DC (1998). "A review of etomidate for rapid sequence intubation in the emergency department". The Journal of Emergency Medicine. 15 (2): 221–230. doi:10.1016/S0736-4679(96)00350-2. PMID 9144065.
  6. ^ "Coronavirus (COVID-19) Update: December 22, 2020". U.S. Food and Drug Administration. 22 December 2020. Retrieved 23 December 2020. Public Domain This article incorporates text from this source, which is in the public domain.