Etoxeridine

Etoxeridine
Clinical data
Other names	Etoxeridine, Carbetidine, Atenos
ATC code	none;
Legal status
Legal status	AU: S9 (Prohibited substance); BR: Class A1 (Narcotic drugs); CA: Schedule I; DE: Anlage I (Authorized scientific use only); UK: Class A; US: Schedule I;
Identifiers
	IUPAC name Ethyl 1-[2-(2-hydroxyethoxy)ethyl]-4-phenylpiperidine-4-carboxylate;
CAS Number	469-82-9 ;
PubChem CID	61122;
DrugBank	DB01505 ;
ChemSpider	55070 ;
UNII	RHW35E1G7E;
KEGG	D12680 ;
ChEMBL	ChEMBL2104254;
CompTox Dashboard (EPA)	DTXSID30196980 ;
ECHA InfoCard	100.006.750
Chemical and physical data
Formula	C18H27NO4
Molar mass	321.417 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1(CCN(CC1)CCOCCO)(C(=O)OCC)C2=CC=CC=C2;
	InChI InChI=1S/C18H27NO4/c1-2-23-17(21)18(16-6-4-3-5-7-16)8-10-19(11-9-18)12-14-22-15-13-20/h3-7,20H,2,8-15H2,1H3 ; Key:KJTKYGFGPQSRRA-UHFFFAOYSA-N ;
	(verify)

Etoxeridine (Carbetidine, Atenos) is a 4-phenyl piperidine derivative that is related to the clinically used opioid analgesic drug pethidine (meperidine).

Etoxeridine was developed in the 1950s^[2] and investigated for use in surgical anesthesia, however it was never commercialized and is not currently used in medicine.^[3]^[4]^[5] As with other opioids which were not in clinical use during the drafting of the Controlled Substances Act, it is categorized as a Schedule I narcotic.

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ BE 558883
^ Merlevede E, Levis S (1958). "Pharmacological study of carbetidine, a new synthetic analgesic". Archives Internationales de Pharmacodynamie et de Thérapie (in French). 115 (1–2): 213–232. PMID 13545901.
^ Sironi PG (1959). "Brief note on a new synthetic analgesic: carbetidine hydrochloride". Minerva Anestesiologica (in Italian). 25 (6): 251–254. PMID 13674097.
^ Crawford JS, Foldes FF (August 1959). "Studies on the respiratory and circulatory effects of carbetidine HCI used for supplementation of thiopentone sodium-nitrous oxide-oxygen anaesthesia". British Journal of Anaesthesia. 31 (8): 348–51. doi:10.1093/bja/31.8.348. PMID 13812715.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] BE 558883

[3] Merlevede E, Levis S (1958). "Pharmacological study of carbetidine, a new synthetic analgesic". Archives Internationales de Pharmacodynamie et de Thérapie (in French). 115 (1–2): 213–232. PMID 13545901.

[4] Sironi PG (1959). "Brief note on a new synthetic analgesic: carbetidine hydrochloride". Minerva Anestesiologica (in Italian). 25 (6): 251–254. PMID 13674097.

[5] Crawford JS, Foldes FF (August 1959). "Studies on the respiratory and circulatory effects of carbetidine HCI used for supplementation of thiopentone sodium-nitrous oxide-oxygen anaesthesia". British Journal of Anaesthesia. 31 (8): 348–51. doi:10.1093/bja/31.8.348. PMID 13812715.

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