Eudysmic ratio

The eudysmic ratio (also spelled eudismic ratio) represents the difference in pharmacologic activity between the two enantiomers of a drug. In most cases where a chiral compound is biologically active, one enantiomer is more active than the other. The eudysmic ratio is the ratio of activity between the two. A eudysmic ratio significantly differing from 1 means that they are statistically different in activity. Eudisimic ratio (ER) reflects the degree of enantioselectivity of the biological systems.[1][2] For example, (S)-propranolol (ER = 130) meaning that (S)-propranolol is 130 times more active than its (R)-enantiomer.[3]

  1. ^ Ariëns, Everardus J. (1986). "Stereochemistry: A source of problems in medicinal chemistry". Medicinal Research Reviews. 6 (4): 451–466. doi:10.1002/med.2610060404. ISSN 0198-6325. PMID 3534485. S2CID 36115871.
  2. ^ Ariëns, E. J. (1984). "Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology". European Journal of Clinical Pharmacology. 26 (6): 663–668. doi:10.1007/BF00541922. ISSN 0031-6970. PMID 6092093. S2CID 30916093.
  3. ^ Sheldon, Roger A. (1993). Chirotechnology : industrial synthesis of optically active compounds. New York: Marcel Dekker. ISBN 0-8247-9143-6. OCLC 27897833.