Eukaryotic translation initiation factor 4 gamma 1

EIF4G1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LJ2, 1UG3, 2W97, 4AZA, 4F02
Identifiers
Aliases	EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18, Eukaryotic translation initiation factor 4 gamma, eukaryotic translation initiation factor 4 gamma 1
External IDs	OMIM: 600495; MGI: 2384784; HomoloGene: 110725; GeneCards: EIF4G1; OMA:EIF4G1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	184,335,358 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	20,511,634 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; skin of leg; ; skin of abdomen; ; stromal cell of endometrium; ; right lobe of liver; ; muscle of thigh; ; right lobe of thyroid gland; ; anterior pituitary; ; apex of heart; ; right adrenal gland;
	Top expressed in
	lacrimal gland; ; tail of embryo; ; primitive streak; ; genital tubercle; ; ventricular zone; ; somite; ; muscle of thigh; ; hair follicle; ; submandibular gland; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	translation initiation factor activity; protein binding; RNA binding; mRNA binding; ATP binding; translation factor activity, RNA binding; eukaryotic initiation factor 4E binding; translation initiation factor binding; molecular adaptor activity; cadherin binding; identical protein binding;
Cellular component	cytosol; membrane; nucleus; cytoplasm; polysome; eukaryotic translation initiation factor 4F complex; cytosolic small ribosomal subunit; postsynapse;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; regulation of mRNA stability; behavioral fear response; positive regulation of neuron differentiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; viral process; regulation of translation; regulation of translational initiation; cap-dependent translational initiation; protein biosynthesis; translational initiation; mitochondrion organization; positive regulation of cell population proliferation; negative regulation of autophagy; negative regulation of peptidyl-threonine phosphorylation; positive regulation of cell growth; positive regulation of protein metabolic process; developmental process; positive regulation of peptidyl-serine phosphorylation; cellular macromolecule biosynthetic process; regulation of gene silencing by miRNA; regulation of cellular response to stress; positive regulation of G1/S transition of mitotic cell cycle; negative regulation of neuron death; positive regulation of eukaryotic translation initiation factor 4F complex assembly; regulation of presynapse assembly; positive regulation of mRNA cap binding; regulation of polysome binding; positive regulation of cell death; cellular response to nutrient levels; energy homeostasis; lung development; response to ethanol;
	Sources:Amigo / QuickGO
Orthologs
	1981
	208643
	ENSG00000114867
	ENSMUSG00000045983
	Q04637
	Q6NZJ6
NM_198244; NM_001194946; NM_001194947; NM_001291157; NM_004953;
	NM_182917; NM_198241; NM_198242
	NM_001005331; NM_145941; NM_001304432
NP_001181875; NP_001181876; NP_001278086; NP_004944; NP_886553;
	NP_937884; NP_937885; NP_937887
NP_001291361; NP_666053; NP_001390389; NP_001390390; NP_001390391;
	NP_001390392; NP_001390393; NP_001390394; NP_001390395; NP_001390396; NP_001390397
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114867 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045983 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yan R, Rychlik W, Etchison D, Rhoads RE (Nov 1992). "Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma". The Journal of Biological Chemistry. 267 (32): 23226–31. doi:10.1016/S0021-9258(18)50080-6. PMID 1429670.
^ Imataka H, Sonenberg N (Dec 1997). "Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A". Molecular and Cellular Biology. 17 (12): 6940–7. doi:10.1128/mcb.17.12.6940. PMC 232551. PMID 9372926.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114867 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045983 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1429670-5] Yan R, Rychlik W, Etchison D, Rhoads RE (Nov 1992). "Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma". The Journal of Biological Chemistry. 267 (32): 23226–31. doi:10.1016/S0021-9258(18)50080-6. PMID 1429670.

[pmid9372926-6] Imataka H, Sonenberg N (Dec 1997). "Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A". Molecular and Cellular Biology. 17 (12): 6940–7. doi:10.1128/mcb.17.12.6940. PMC 232551. PMID 9372926.

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