Euphemia of Greater Poland (Polish: Eufemia Odonicówna) (c. 1230 – 15 February after 1281), was a Polish princess member of the House of Piast from the Greater Poland branch and by marriage was Duchess of Kalisz, Wieluń and Opole-Racibórz.
Euphemia was the youngest child of Władysław Odonic and his wife Jadwiga, disputed daughter of Mestwin I, Duke of Pomerania and Swinisław, daughter of Mieszko III the Old.
Euphemia's date of birth is unknown. In literature it claims Euphemia was born around 1230. It is most likely she was born between (1226–1230), fitting in with the dates of birth of her siblings and dates of death of her parents.