Excitatory amino acid transporter 3

SLC1A1
Identifiers
Aliases	SLC1A1, EAAC1, EAAT3, SCZD18, DCBXA, solute carrier family 1 member 1
External IDs	OMIM: 133550; MGI: 105083; HomoloGene: 20881; GeneCards: SLC1A1; OMA:SLC1A1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	4,587,469 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	28,891,360 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; jejunal mucosa; ; mucosa of ileum; ; kidney tubule; ; pancreatic ductal cell; ; duodenum; ; decidua; ; lower lobe of lung; ; postcentral gyrus; ; endothelial cell;
	Top expressed in
	retinal pigment epithelium; ; subiculum; ; right kidney; ; lateral geniculate nucleus; ; human kidney; ; lumbar subsegment of spinal cord; ; medial geniculate nucleus; ; Region I of hippocampus proper; ; proximal tubule; ; lateral septal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cysteine transmembrane transporter activity; protein binding; symporter activity; L-glutamate transmembrane transporter activity; glutamate binding; amino acid transmembrane transporter activity; high-affinity glutamate transmembrane transporter activity; chloride transmembrane transporter activity; glutamate:sodium symporter activity; metal ion binding;
Cellular component	integral component of membrane; membrane; plasma membrane; apical plasma membrane; extracellular exosome; integral component of plasma membrane; early endosome membrane; recycling endosome membrane;
Biological process	chemical synaptic transmission; D-aspartate import across plasma membrane; ion transport; positive regulation of heart rate; glutamate secretion; cysteine transport; protein homooligomerization; L-glutamate import; L-glutamate transmembrane transport; cysteine transmembrane transport; L-aspartate import across plasma membrane; chloride transmembrane transport; L-glutamate import across plasma membrane; amino acid transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	6505
	20510
	ENSG00000106688
	ENSMUSG00000024935
	P43005
	P51906
	NM_004170
	NM_009199
	NP_004161
	NP_033225
	Wikidata
View/Edit Human	View/Edit Mouse

Excitatory amino acid transporter 3 (EAAT3), is a protein that in humans is encoded by the SLC1A1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106688 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024935 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith CP, Weremowicz S, Kanai Y, Stelzner M, Morton CC, Hediger MA (March 1994). "Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders". Genomics. 20 (2): 335–6. doi:10.1006/geno.1994.1183. PMID 8020993.
^ "Entrez Gene: SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106688 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024935 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8020993-5] Smith CP, Weremowicz S, Kanai Y, Stelzner M, Morton CC, Hediger MA (March 1994). "Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders". Genomics. 20 (2): 335–6. doi:10.1006/geno.1994.1183. PMID 8020993.

[entrez-6] "Entrez Gene: SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1".

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