FADD

FADD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OQ9, 1A1W, 1A1Z, 1E3Y, 1E41, 2GF5, 3EZQ
Identifiers
Aliases	FADD, GIG3, MORT1, Fas associated via death domain, IMD90
External IDs	OMIM: 602457; MGI: 109324; HomoloGene: 2836; GeneCards: FADD; OMA:FADD - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.3 Start 70,203,296 bp[1] End 70,207,390 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte tendon of biceps brachii stromal cell of endometrium mucosa of transverse colon blood parotid gland right adrenal gland right adrenal cortex left adrenal gland epithelium of esophagus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function identical protein binding tumor necrosis factor receptor superfamily binding death effector domain binding caspase binding protein binding protease binding death receptor binding tumor necrosis factor receptor binding receptor serine/threonine kinase binding protein-containing complex binding Cellular component cytosol membrane raft ripoptosome cell body neuron projection CD95 death-inducing signaling complex plasma membrane death-inducing signaling complex cytoplasm nucleus protein-containing complex Biological process TRAIL-activated apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors motor neuron apoptotic process immune system process necroptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of necroptotic process positive regulation of interleukin-8 production positive regulation of type I interferon-mediated signaling pathway cell surface receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway positive regulation of macrophage differentiation defense response to virus activation of cysteine-type endopeptidase activity apoptotic signaling pathway cellular response to mechanical stimulus extrinsic apoptotic signaling pathway in absence of ligand positive regulation of transcription by RNA polymerase II extrinsic apoptotic signaling pathway via death domain receptors regulation of apoptotic process death-inducing signaling complex assembly positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of tumor necrosis factor production positive regulation of I-kappaB kinase/NF-kappaB signaling signal transduction positive regulation of proteolysis viral process apoptotic process positive regulation of activated T cell proliferation extrinsic apoptotic signaling pathway positive regulation of T cell mediated cytotoxicity positive regulation of extrinsic apoptotic signaling pathway thymus development positive regulation of adaptive immune response T cell differentiation in thymus innate immune response spleen development negative regulation of activation-induced cell death of T cells negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of interferon-gamma production positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation lymph node development T cell homeostasis response to cocaine response to morphine behavioral response to cocaine regulation of necroptotic process positive regulation of apoptotic process toll-like receptor 3 signaling pathway kidney development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8772 14082 Ensembl ENSG00000168040 ENSMUSG00000031077 UniProt Q13158 Q61160 RefSeq (mRNA) NM_003824 NM_010175 RefSeq (protein) NP_003815 NP_034305 Location (UCSC) Chr 11: 70.2 – 70.21 Mb n/a PubMed search [2] [3]
Wikidata
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FAS-associated death domain protein, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans.^[4]

FADD is an adaptor protein that bridges members of the tumor necrosis factor receptor superfamily, such as the Fas-receptor, to procaspases 8 and 10 to form the death-inducing signaling complex (DISC) during apoptosis. As well as its most well known role in apoptosis, FADD has also been seen to play a role in other processes including proliferation, cell cycle regulation and development.