FAM98A

FAM98A
Identifiers
Aliases	FAM98A, family with sequence similarity 98 member A
External IDs	MGI: 1919972; HomoloGene: 41042; GeneCards: FAM98A; OMA:FAM98A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	33,599,347 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	75,858,941 bp
RNA expression pattern
	Top expressed in
	tibia; ; male germ cell; ; sperm; ; smooth muscle tissue; ; pons; ; inferior ganglion of vagus nerve; ; right ventricle; ; biceps brachii; ; endothelial cell; ; Epithelium of choroid plexus;
	Top expressed in
	saccule; ; otic placode; ; otic vesicle; ; lacrimal gland; ; cumulus cell; ; parotid gland; ; pituitary gland; ; seminiferous tubule; ; dermis; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; RNA binding; protein methyltransferase activity;
Cellular component	tRNA-splicing ligase complex;
Biological process	protein methylation; positive regulation of cell population proliferation; positive regulation of gene expression; lysosome localization; positive regulation of ruffle assembly;
	Sources:Amigo / QuickGO
Orthologs
	25940
	72722
	ENSG00000119812
	ENSMUSG00000002017
	Q8NCA5
	Q3TJZ6
	NM_015475; NM_001304538
	NM_133747; NM_001357860
	NP_001291467; NP_056290; NP_001291467.1; NP_056290.3
	NP_598508; NP_001344789
	Wikidata
View/Edit Human	View/Edit Mouse

Family with sequence similarity 98, member A, or FAM98A, is a gene that in the human genome encodes the FAM98A protein. FAM98A has two paralogs in humans, FAM98B and FAM98C. All three are characterized by DUF2465, a conserved domain shown to bind to RNA.^[5] FAM98A is also characterized by a glycine-rich C-terminal domain.^[6] FAM98A also has homologs in vertebrates and invertebrates and has distant homologs in choanoflagellates and green algae.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119812 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002017 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dürnberger G, Bürckstümmer T, Huber K, Giambruno R, Doerks T, Karayel E, Burkard TR, Kaupe I, Müller AC, Schönegger A, Ecker GF, Lohninger H, Bork P, Bennett KL, Superti-Furga G, Colinge J (July 2013). "Experimental characterization of the human non-sequence-specific nucleic acid interactome". Genome Biology. 14 (7): R81. doi:10.1186/gb-2013-14-7-r81. PMC 4053969. PMID 23902751.
^ "Pfam: Family: DUF2465 (PF10239)". Pfam. EMBL-EBI. Retrieved 5 May 2014.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119812 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002017 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Dürnberger-5] Dürnberger G, Bürckstümmer T, Huber K, Giambruno R, Doerks T, Karayel E, Burkard TR, Kaupe I, Müller AC, Schönegger A, Ecker GF, Lohninger H, Bork P, Bennett KL, Superti-Furga G, Colinge J (July 2013). "Experimental characterization of the human non-sequence-specific nucleic acid interactome". Genome Biology. 14 (7): R81. doi:10.1186/gb-2013-14-7-r81. PMC 4053969. PMID 23902751.

[6] "Pfam: Family: DUF2465 (PF10239)". Pfam. EMBL-EBI. Retrieved 5 May 2014.

[1]

[2]

[3]

[4]

[5]

[6]