FARSA (gene)

FARSA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L4G
Identifiers
Aliases	FARSA, CML33, FARSL, FARSLA, FRSA, PheHA, phenylalanyl-tRNA synthetase alpha subunit, phenylalanyl-tRNA synthetase subunit alpha, RILDBC2
External IDs	OMIM: 602918; MGI: 1913840; HomoloGene: 3280; GeneCards: FARSA; OMA:FARSA - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,934,037 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,595,886 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; mucosa of transverse colon; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; Brodmann area 10; ; gastrocnemius muscle; ; apex of heart; ; ganglionic eminence;
	Top expressed in
	spermatocyte; ; spermatid; ; embryo; ; morula; ; embryo; ; ventricular zone; ; neural layer of retina; ; blastocyst; ; yolk sac; ; lip;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; tRNA binding; nucleotide binding; ligase activity; protein binding; ATP binding; phenylalanine-tRNA ligase activity; RNA binding;
Cellular component	cytoplasm; cytosol; membrane; phenylalanine-tRNA ligase complex;
Biological process	tRNA aminoacylation; protein biosynthesis; protein heterotetramerization; tRNA aminoacylation for protein translation; phenylalanyl-tRNA aminoacylation;
	Sources:Amigo / QuickGO
Orthologs
	2193
	66590
	ENSG00000179115
	ENSMUSG00000003808
	Q9Y285
	Q8C0C7
	NM_004461
	NM_025648
	NP_004452
	NP_079924
	Wikidata
View/Edit Human	View/Edit Mouse

Phenylalanyl-tRNA synthetase alpha chain is an enzyme that in humans is encoded by the FARSA gene.^[5]^[6]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179115 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003808 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA (Jul 1997). "Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent". Proc Natl Acad Sci U S A. 94 (12): 6164–9. Bibcode:1997PNAS...94.6164S. doi:10.1073/pnas.94.12.6164. PMC 21020. PMID 9177188.
^ ^a ^b "Entrez Gene: FARSA phenylalanyl-tRNA synthetase, alpha subunit".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179115 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003808 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9177188-5] Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA (Jul 1997). "Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent". Proc Natl Acad Sci U S A. 94 (12): 6164–9. Bibcode:1997PNAS...94.6164S. doi:10.1073/pnas.94.12.6164. PMC 21020. PMID 9177188.

[entrez-6] "Entrez Gene: FARSA phenylalanyl-tRNA synthetase, alpha subunit".

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