FBXO2

FBXO2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UMH, 1UMI, 2E31, 2E32, 2E33, 2RJ2
Identifiers
Aliases	FBXO2, FBG1, FBX2, Fbs1, NFB42, OCP1, F-box protein 2
External IDs	OMIM: 607112; MGI: 2446216; HomoloGene: 8132; GeneCards: FBXO2; OMA:FBXO2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	11,655,785 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	148,250,881 bp
RNA expression pattern
	Top expressed in
	amygdala; ; C1 segment; ; right frontal lobe; ; anterior cingulate cortex; ; caudate nucleus; ; Brodmann area 9; ; putamen; ; nucleus accumbens; ; right hemisphere of cerebellum; ; prefrontal cortex;
	Top expressed in
	vestibular membrane of cochlear duct; ; utricle; ; vestibular sensory epithelium; ; facial motor nucleus; ; anterior horn of spinal cord; ; optic nerve; ; stria vascularis; ; pontine nuclei; ; medial vestibular nucleus; ; cochlea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	amyloid-beta binding; carbohydrate binding; ubiquitin-protein transferase activity; protein binding; ubiquitin protein ligase activity;
Cellular component	organelle membrane; membrane; SCF ubiquitin ligase complex; intracellular membrane-bounded organelle; dendritic spine; endoplasmic reticulum; cytosol; cytoplasm;
Biological process	ubiquitin-dependent protein catabolic process; regulation of protein ubiquitination; proteolysis; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; ubiquitin-dependent ERAD pathway; glycoprotein catabolic process; negative regulation of cell population proliferation; protein polyubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	26232
	230904
	ENSG00000116661
	ENSMUSG00000041556
	Q9UK22
	Q80UW2
	NM_012168
	NM_176848
	NP_036300
	NP_789818
	Wikidata
View/Edit Human	View/Edit Mouse

F-box only protein 2 is a protein that in humans is encoded by the FBXO2 gene.^[5]^[6]^[7]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116661 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041556 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
^ ^a ^b "Entrez Gene: FBXO2 F-box protein 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116661 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041556 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10531035-5] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.

[pmid10531037-6] Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.

[entrez-7] "Entrez Gene: FBXO2 F-box protein 2".

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