FHIT

FHIT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FHI, 2FHI, 2FIT, 5FIT, 3FIT, 1FIT, 4FIT, 6FIT
Identifiers
Aliases	FHIT, AP3Aase, FRA3B, fragile histidine triad, tríada histidina fràgil, fragile histidine triad diadenosine triphosphatase
External IDs	OMIM: 601153; MGI: 1277947; HomoloGene: 21661; GeneCards: FHIT; OMA:FHIT - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	61,251,459 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	12,919,681 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; apex of heart; ; C1 segment; ; gallbladder; ; oocyte; ; right auricle; ; testicle; ; human kidney;
	Top expressed in
	right kidney; ; lumbar spinal ganglion; ; transitional epithelium of urinary bladder; ; Epithelium of choroid plexus; ; motor neuron; ; saccule; ; proximal tubule; ; choroid plexus of fourth ventricle; ; seminal vesicula; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	bis(5'-adenosyl)-triphosphatase activity; nucleotide binding; catalytic activity; hydrolase activity; protein binding; ubiquitin protein ligase binding; identical protein binding;
Cellular component	cytoplasm; cytosol; mitochondrion; nucleus; fibrillar center; plasma membrane;
Biological process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process; purine nucleotide metabolic process; regulation of transcription, DNA-templated; nucleotide metabolic process; transcription, DNA-templated; intrinsic apoptotic signaling pathway by p53 class mediator; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	2272
	14198
	ENSG00000189283
	ENSMUSG00000060579
	P49789
	O89106
NM_001166243; NM_002012; NM_001320899; NM_001320900; NM_001320901;
	NM_001354589; NM_001354590
	NM_010210; NM_001308285; NM_001308286; NM_001360141
NP_001159715; NP_001307828; NP_001307829; NP_001307830; NP_002003;
	NP_001341518; NP_001341519
	NP_001295214; NP_001295215; NP_034340; NP_001347070
	Wikidata
View/Edit Human	View/Edit Mouse

Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000189283 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060579 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohta MH, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce CM, Huebner K (Apr 1996). "The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers". Cell. 84 (4): 587–97. doi:10.1016/S0092-8674(00)81034-X. PMID 8598045. S2CID 18792069.
^ Pekarsky Y, Campiglio M, Siprashvili Z, Druck T, Sedkov Y, Tillib S, Draganescu A, Wermuth P, Rothman JH, Huebner K, Buchberg AM, Mazo A, Brenner C, Croce CM (Aug 1998). "Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8744–9. Bibcode:1998PNAS...95.8744P. doi:10.1073/pnas.95.15.8744. PMC 21147. PMID 9671749.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000189283 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060579 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8598045-5] Ohta MH, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce CM, Huebner K (Apr 1996). "The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers". Cell. 84 (4): 587–97. doi:10.1016/S0092-8674(00)81034-X. PMID 8598045. S2CID 18792069.

[pmid9671749-6] Pekarsky Y, Campiglio M, Siprashvili Z, Druck T, Sedkov Y, Tillib S, Draganescu A, Wermuth P, Rothman JH, Huebner K, Buchberg AM, Mazo A, Brenner C, Croce CM (Aug 1998). "Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8744–9. Bibcode:1998PNAS...95.8744P. doi:10.1073/pnas.95.15.8744. PMC 21147. PMID 9671749.

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