FNTB

FNTB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JCQ, 1LD7, 1LD8, 1MZC, 1S63, 1SA4, 1TN6, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, 2IEJ, 3E37
Identifiers
Aliases	FNTB, FPTB, farnesyltransferase, CAAX box, beta
External IDs	OMIM: 134636; MGI: 1861305; HomoloGene: 1535; GeneCards: FNTB; OMA:FNTB - orthologs
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	76,968,186 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; substantia nigra; ; gastrocnemius muscle; ; tibial nerve; ; skin of abdomen; ; right uterine tube; ; sural nerve; ; pituitary gland; ; hippocampus proper; ; vagina;
	Top expressed in
	yolk sac; ; lip; ; genital tubercle; ; neural layer of retina; ; tail of embryo; ; muscle of thigh; ; esophagus; ; neural tube; ; cerebellar cortex; ; epiblast;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; transferase activity; prenyltransferase activity; catalytic activity; protein farnesyltransferase activity; protein binding; farnesyltranstransferase activity; zinc ion binding; isoprenoid binding; peptide binding;
Cellular component	cytosol; protein farnesyltransferase complex; microtubule associated complex; protein-containing complex;
Biological process	protein farnesylation; positive regulation of cell population proliferation; negative regulation of cell population proliferation; response to inorganic substance; response to organic cyclic compound; response to cytokine; wound healing; positive regulation of cell cycle; positive regulation of fibroblast proliferation; positive regulation of nitric-oxide synthase biosynthetic process; protein prenylation; regulation of fibroblast proliferation; regulation of rhodopsin mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2342
	110606
	n/a
	ENSMUSG00000033373
	P49356
	Q8K2I1
	NM_002028
	NM_145927
	NP_002019; NP_001189487; NP_001189488
	NP_666039
	Wikidata
View/Edit Human	View/Edit Mouse

Protein farnesyltransferase subunit beta is an enzyme that in humans is encoded by the FNTB gene.^[4]^[5]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033373 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Andres DA, Milatovich A, Ozcelik T, Wenzlau JM, Brown MS, Goldstein JL, Francke U (Feb 1994). "cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences". Genomics. 18 (1): 105–12. doi:10.1006/geno.1993.1432. PMID 8276393.
^ "Entrez Gene: FNTB farnesyltransferase, CAAX box, beta".

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000033373 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8276393-4] Andres DA, Milatovich A, Ozcelik T, Wenzlau JM, Brown MS, Goldstein JL, Francke U (Feb 1994). "cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences". Genomics. 18 (1): 105–12. doi:10.1006/geno.1993.1432. PMID 8276393.

[entrez-5] "Entrez Gene: FNTB farnesyltransferase, CAAX box, beta".

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