FOSL1

FOSL1
Identifiers
Aliases	FOSL1, FRA, FRA1, fra-1, FOS like 1, AP-1 transcription factor subunit
External IDs	OMIM: 136515; MGI: 107179; HomoloGene: 3967; GeneCards: FOSL1; OMA:FOSL1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,900,573 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,505,974 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; stromal cell of endometrium; ; gallbladder; ; vena cava; ; mucosa of urinary bladder; ; mucosa of esophagus; ; testicle; ; islet of Langerhans; ; ascending aorta; ; cervix epithelium;
	Top expressed in
	endothelial cell of lymphatic vessel; ; granulocyte; ; decidua; ; embryo; ; embryo; ; gastrula; ; stroma of bone marrow; ; supraoptic nucleus; ; lip; ; ascending aorta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytosol; intracellular membrane-bounded organelle; neuron projection; presynaptic membrane; nucleus; nucleoplasm;
Biological process	cellular response to extracellular stimulus; response to cytokine; regulation of transcription, DNA-templated; response to organic cyclic compound; vitellogenesis; regulation of transcription by RNA polymerase II; response to progesterone; female pregnancy; response to corticosterone; response to mechanical stimulus; response to virus; positive regulation of DNA-binding transcription factor activity; placenta blood vessel development; in utero embryonic development; learning; positive regulation of DNA-templated transcription, initiation; chemotaxis; response to gravity; cellular defense response; positive regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of apoptotic process; response to cAMP; response to hydrogen peroxide; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; pri-miRNA transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8061
	14283
	ENSG00000175592
	ENSMUSG00000024912
	P15407
	P48755
	NM_001300844; NM_001300855; NM_001300856; NM_001300857; NM_005438
	NM_010235
	NP_001287773; NP_001287784; NP_001287785; NP_001287786; NP_005429
	NP_034365
	Wikidata
View/Edit Human	View/Edit Mouse

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175592 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024912 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Mar 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–255. PMID 2107490.
^ "Entrez Gene: FOSL1 FOS-like antigen 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175592 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024912 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2107490-5] Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Mar 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–255. PMID 2107490.

[entrez-6] "Entrez Gene: FOSL1 FOS-like antigen 1".

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