FOXC2

FOXC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D5V
Identifiers
Aliases	FOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C2
External IDs	OMIM: 602402; MGI: 1347481; HomoloGene: 21091; GeneCards: FOXC2; OMA:FOXC2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.1 Start 86,566,829 bp[1] End 86,569,728 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E1|8 70.33 cM Start 121,842,910 bp[2] End 121,845,634 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava palpebral conjunctiva popliteal artery trigeminal ganglion tibial arteries urethra ascending aorta spinal ganglia Descending thoracic aorta cardiac muscle tissue of right atrium Top expressed in aortic arches ascending aorta fifth metatarsal bone renal corpuscle optic nerve aortic valve fourth metatarsal bone somite sclerotome lumbar spinal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific protein binding identical protein binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding chromatin DNA binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus nucleoplasm nuclear body Biological process Notch signaling pathway somitogenesis embryonic skeletal system morphogenesis skeletal system development insulin receptor signaling pathway ureteric bud development regulation of transcription, DNA-templated positive regulation of cell migration involved in sprouting angiogenesis neural crest cell development paraxial mesoderm formation paraxial mesodermal cell fate commitment ossification lymphangiogenesis collagen fibril organization kidney development glomerular mesangial cell development heart morphogenesis negative regulation of transcription by RNA polymerase II cardiac muscle cell proliferation lymph vessel development transcription, DNA-templated embryonic heart tube development positive regulation of endothelial cell migration positive regulation of transcription, DNA-templated multicellular organism development ventricular cardiac muscle tissue morphogenesis heart development blood vessel remodeling vascular endothelial growth factor receptor signaling pathway blood vessel development positive regulation of vascular wound healing artery morphogenesis branching involved in blood vessel morphogenesis glomerular visceral epithelial cell differentiation response to hormone embryonic viscerocranium morphogenesis embryonic cranial skeleton morphogenesis camera-type eye development glomerular endothelium development positive regulation of cell adhesion mediated by integrin mesoderm development regulation of organ growth metanephros development cell population proliferation positive regulation of transcription by RNA polymerase II negative regulation of apoptotic process involved in outflow tract morphogenesis transcription by RNA polymerase II cell differentiation regulation of transcription by RNA polymerase II anatomical structure morphogenesis negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2303 14234 Ensembl ENSG00000176692 ENSMUSG00000046714 UniProt Q99958 Q61850 RefSeq (mRNA) NM_005251 NM_013519 RefSeq (protein) NP_005242 NP_038547 Location (UCSC) Chr 16: 86.57 – 86.57 Mb Chr 8: 121.84 – 121.85 Mb PubMed search [3] [4]
Wikidata
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Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1 (MFH1) is a protein that in humans is encoded by the FOXC2 gene.^[5][6] FOXC2 is a member of the fork head box (FOX) family of transcription factors.