FOXD3

FOXD3
Identifiers
Aliases	FOXD3, AIS1, Genesis, HFH2, VAMAS2, forkhead box D3
External IDs	OMIM: 611539; MGI: 1347473; HomoloGene: 49239; GeneCards: FOXD3; OMA:FOXD3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	63,325,128 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	99,546,859 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; spinal ganglia; ; trigeminal ganglion; ; muscle layer of sigmoid colon; ; gastric mucosa; ; right auricle; ; seminal vesicula; ; left coronary artery; ; transverse colon; ; olfactory zone of nasal mucosa;
	Top expressed in
	neural crest; ; epiblast; ; spinal cord; ; urethra; ; ureter; ; Neural groove; ; neural fold; ; salivary gland; ; embryo; ; spinal ganglia;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus;
Biological process	negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; multicellular organism development; somatic stem cell population maintenance; in utero embryonic development; transcription, DNA-templated; anatomical structure morphogenesis; cell differentiation; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	27022
	15221
	ENSG00000187140
	ENSMUSG00000067261
	Q9UJU5
	Q61060
	NM_012183
	NM_010425
	NP_036315
	NP_034555
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box D3 also known as FOXD3 is a forkhead protein that in humans is encoded by the FOXD3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187140 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067261 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hromas R, Moore J, Johnston T, Socha C, Klemsz M (June 1993). "Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells". Blood. 81 (11): 2854–2859. doi:10.1182/blood.V81.11.2854.2854. PMID 8499623.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187140 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067261 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8499623-5] Hromas R, Moore J, Johnston T, Socha C, Klemsz M (June 1993). "Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells". Blood. 81 (11): 2854–2859. doi:10.1182/blood.V81.11.2854.2854. PMID 8499623.

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