FOXO3

FOXO3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K86, 2LQH, 2LQI, 2UZK
Identifiers
Aliases	FOXO3, AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box O3
External IDs	OMIM: 602681; MGI: 1890081; HomoloGene: 31039; GeneCards: FOXO3; OMA:FOXO3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	108,684,774 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	42,152,751 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; trabecular bone; ; cerebellar vermis; ; nipple; ; middle temporal gyrus; ; visceral pleura; ; buccal mucosa cell; ; tibialis anterior muscle; ; pericardium; ; parietal pleura;
	Top expressed in
	secondary oocyte; ; zygote; ; fetal liver hematopoietic progenitor cell; ; primary oocyte; ; ciliary body; ; aortic valve; ; ascending aorta; ; cumulus cell; ; blood; ; fossa;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	beta-catenin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; protein kinase binding; chromatin DNA binding; DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; mitochondrial transcription factor activity; transcription coregulator binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription factor binding;
Cellular component	membrane; nucleoplasm; cytosol; cytoplasm; nucleus; mitochondrion; mitochondrial outer membrane; mitochondrial matrix; protein-containing complex;
Biological process	initiation of primordial ovarian follicle growth; ovulation from ovarian follicle; regulation of transcription, DNA-templated; antral ovarian follicle growth; positive regulation of erythrocyte differentiation; glucose homeostasis; DNA damage response, signal transduction by p53 class mediator; tumor necrosis factor-mediated signaling pathway; regulation of reactive oxygen species metabolic process; transcription by RNA polymerase II; regulation of neural precursor cell proliferation; transcription, DNA-templated; neuronal stem cell population maintenance; positive regulation of neuron apoptotic process; oocyte maturation; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of apoptotic process; regulation of translation; negative regulation of canonical Wnt signaling pathway; apoptotic process; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; cellular response to oxidative stress; positive regulation of transcription, DNA-templated; positive regulation of reactive oxygen species biosynthetic process; brain morphogenesis; ageing; negative regulation of neuron differentiation; cellular response to hypoxia; response to water-immersion restraint stress; response to nutrient levels; cellular response to amyloid-beta; cellular response to corticosterone stimulus; positive regulation of endothelial cell apoptotic process; positive regulation of hydrogen peroxide-mediated programmed cell death; response to dexamethasone; cellular response to nerve growth factor stimulus; cellular response to glucose stimulus; anatomical structure morphogenesis; cytokine-mediated signaling pathway; mitochondrial transcription; negative regulation of cell migration; insulin receptor signaling pathway; positive regulation of autophagy; positive regulation of muscle atrophy; response to starvation;
	Sources:Amigo / QuickGO
Orthologs
	2309
	56484
	ENSG00000118689
	ENSMUSG00000048756
	O43524
	Q9WVH4
	NM_001455; NM_201559
	NM_019740; NM_001376967
	NP_001446; NP_963853
	NP_062714; NP_001363896
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118689 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048756 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC (January 1998). "Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily". Genomics. 47 (2): 187–199. doi:10.1006/geno.1997.5122. PMID 9479491.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118689 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048756 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9479491-5] Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC (January 1998). "Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily". Genomics. 47 (2): 187–199. doi:10.1006/geno.1997.5122. PMID 9479491.

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