FOXP3

FOXP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QRF, 4WK8
Identifiers
Aliases	FOXP3, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3
External IDs	OMIM: 300292; MGI: 1891436; HomoloGene: 8516; GeneCards: FOXP3; OMA:FOXP3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 49,250,438 bp[1] End 49,270,477 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A1.1|X 3.41 cM Start 7,439,883 bp[2] End 7,461,484 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle tendon of biceps brachii lymph node cecum appendix blood tonsil gallbladder granulocyte Top expressed in urethra male urethra blastocyst embryo pharynx thymus meninges tail of embryo dentate gyrus of hippocampal formation granule cell neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding NF-kappaB binding transcription corepressor activity nucleic acid binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding histone deacetylase binding DNA-binding transcription factor activity NFAT protein binding histone acetyltransferase binding metal ion binding DNA binding protein homodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus intracellular anatomical structure cytoplasm nucleoplasm protein-containing complex Biological process negative regulation of cell population proliferation negative regulation of NF-kappaB transcription factor activity B cell homeostasis regulation of isotype switching to IgG isotypes myeloid cell homeostasis negative regulation of inflammatory response positive regulation of interleukin-4 production regulation of immunoglobulin production regulation of transcription by RNA polymerase II regulation of T cell anergy negative regulation of interleukin-6 production tolerance induction to self antigen regulation of transcription, DNA-templated negative regulation of DNA-binding transcription factor activity positive regulation of T cell tolerance induction negative regulation of immune response negative regulation of interferon-gamma production tolerance induction regulatory T cell differentiation positive regulation of transcription, DNA-templated negative regulation of interleukin-2 production positive regulation of histone acetylation negative regulation of interleukin-5 production negative regulation of chronic inflammatory response CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of activated T cell proliferation positive regulation of gene expression negative regulation of interleukin-4 production negative regulation of interleukin-10 production negative regulation of tumor necrosis factor production T cell homeostasis negative regulation of CREB transcription factor activity negative regulation of T-helper 17 cell differentiation T cell activation positive regulation of immature T cell proliferation in thymus positive regulation of regulatory T cell differentiation negative regulation of transcription by RNA polymerase II positive regulation of peripheral T cell tolerance induction positive regulation of transforming growth factor beta1 production negative regulation of transcription, DNA-templated negative regulation of lymphocyte proliferation negative regulation of histone acetylation negative regulation of interleukin-17 production response to virus negative regulation of histone deacetylation CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation negative regulation of T cell proliferation chromatin remodeling cytokine production negative regulation of T cell cytokine production negative regulation of isotype switching to IgE isotypes T cell receptor signaling pathway positive regulation of T cell anergy transcription, DNA-templated T cell mediated immunity negative regulation of gene expression anatomical structure morphogenesis regulation of Wnt signaling pathway regulation of regulatory T cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50943 20371 Ensembl ENSG00000049768 ENSMUSG00000039521 UniProt Q9BZS1 Q99JB6 RefSeq (mRNA) NM_001114377 NM_014009 NM_001199347 NM_001199348 NM_054039 RefSeq (protein) NP_001107849 NP_054728 NP_001186276 NP_001186277 NP_473380 Location (UCSC) Chr X: 49.25 – 49.27 Mb Chr X: 7.44 – 7.46 Mb PubMed search [3] [4]
Wikidata
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FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses.^[5] A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells.^[6][7][8] Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.^[9][10]

While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. In regulatory T cell model systems, the FOXP3 transcription factor occupies the promoters for genes involved in regulatory T-cell function, and may inhibit transcription of key genes following stimulation of T cell receptors.^[11]