FUT2

FUT2
Identifiers
Aliases	FUT2, B12QTL1, SE, SEC2, Se2, sej, fucosyltransferase 2
External IDs	OMIM: 182100; MGI: 109374; HomoloGene: 10325; GeneCards: FUT2; OMA:FUT2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,705,951 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,315,818 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; nasal epithelium; ; minor salivary glands; ; pancreatic ductal cell; ; mucosa of transverse colon; ; buccal mucosa cell; ; duodenum; ; oral cavity; ; rectum; ; palpebral conjunctiva;
	Top expressed in
	lip; ; left colon; ; epithelium of stomach; ; skin of external ear; ; seminal vesicula; ; duodenum; ; esophagus; ; migratory enteric neural crest cell; ; skin of back; ; lobe of prostate;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; galactoside 2-alpha-L-fucosyltransferase activity; glycosyltransferase activity; fucosyltransferase activity;
Cellular component	integral component of membrane; Golgi cisterna membrane; Golgi apparatus; extracellular exosome; membrane;
Biological process	protein glycosylation; L-fucose catabolic process; fucosylation; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2524
	14344
	ENSG00000176920
	ENSMUSG00000055978
	Q10981
	Q9JL27
	NM_001097638; NM_000511
	NM_001271993; NM_018876
	NP_000502; NP_001091107
	NP_001258922; NP_061364
	Wikidata
View/Edit Human	View/Edit Mouse

Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene.^[5]^[6] It affects the secretor status of ABO antigens.^[7]

Approximately 20% of Caucasians are non-secretors due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 and therefore have strong although not absolute protection from the norovirus GII.4.^{[citation needed]}

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176920 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055978 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (Feb 1992). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Ann Hum Genet. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885. S2CID 30777695.
^ "Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)".
^ "Names for H (ISBT 018) Blood Group Alleles" (PDF). www.isbtweb.org. Archived from the original (PDF) on 2019-08-28. Retrieved 2019-10-13.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176920 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055978 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1763885-5] Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (Feb 1992). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Ann Hum Genet. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885. S2CID 30777695.

[entrez-6] "Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)".

[7] "Names for H (ISBT 018) Blood Group Alleles" (PDF). www.isbtweb.org. Archived from the original (PDF) on 2019-08-28. Retrieved 2019-10-13.

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