FYN

FYN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A0N, 1AOT, 1AOU, 1AVZ, 1AZG, 1EFN, 1FYN, 1G83, 1M27, 1NYF, 1NYG, 1SHF, 1ZBJ, 2DQ7, 3H0F, 3H0H, 3H0I, 3UA6, 3UA7, 4D8D, 4EIK, 2MQI, 2MRJ, 2MRK, 4U17, 4U1P, 4ZNX
Identifiers
Aliases	FYN, SLK, SYN, p59-FYN proto-oncogene, Src family tyrosine kinase
External IDs	OMIM: 137025; MGI: 95602; HomoloGene: 48068; GeneCards: FYN; OMA:FYN - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 111,660,332 bp[1] End 111,873,452 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B1|10 20.51 cM Start 39,368,855 bp[2] End 39,565,381 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence corpus callosum granulocyte olfactory bulb lymph node optic nerve right lung ventricular zone amygdala dorsal motor nucleus of vagus nerve Top expressed in optic nerve Rostral migratory stream ganglionic eminence dentate gyrus of hippocampal formation granule cell olfactory bulb gastrula ventricular zone zygote barrel cortex secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function CD4 receptor binding transmembrane transporter binding protein-containing complex binding protein binding CD8 receptor binding kinase activity tubulin binding signaling receptor binding ATP binding protein kinase activity metal ion binding peptide hormone receptor binding T cell receptor binding transferase activity ephrin receptor binding nucleotide binding growth factor receptor binding phosphatidylinositol 3-kinase binding G protein-coupled receptor binding non-membrane spanning protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein tyrosine kinase activity enzyme binding identical protein binding signal transducer activity type 5 metabotropic glutamate receptor binding alpha-tubulin binding tau protein binding tau-protein kinase activity disordered domain specific binding Cellular component cytoplasm membrane extrinsic component of cytoplasmic side of plasma membrane mitochondrion nucleus membrane raft intracellular membrane-bounded organelle actin filament cell periphery endosome plasma membrane cytosol postsynaptic density dendrite cell body perinuclear region of cytoplasm perinuclear endoplasmic reticulum glial cell projection Schaffer collateral - CA1 synapse glutamatergic synapse postsynaptic density, intracellular component Biological process negative regulation of neuron apoptotic process adaptive immune response learning platelet activation cell surface receptor signaling pathway vascular endothelial growth factor receptor signaling pathway feeding behavior response to ethanol calcium ion transport regulation of apoptotic process cellular response to transforming growth factor beta stimulus Fc-gamma receptor signaling pathway involved in phagocytosis negative regulation of protein catabolic process transmembrane receptor protein tyrosine kinase signaling pathway stimulatory C-type lectin receptor signaling pathway negative regulation of gene expression protein autophosphorylation T cell activation detection of mechanical stimulus involved in sensory perception of pain cell differentiation dendrite morphogenesis phosphorylation immune system process neuron migration cellular response to platelet-derived growth factor stimulus regulation of cell shape peptidyl-tyrosine autophosphorylation phosphatidylinositol-mediated signaling leukocyte migration positive regulation of protein localization to nucleus intracellular signal transduction activated T cell proliferation ephrin receptor signaling pathway cellular response to growth factor stimulus T cell costimulation blood coagulation mitigation of host defenses by virus MAPK cascade axon guidance multicellular organism development negative regulation of protein ubiquitination cellular response to peptide hormone stimulus regulation of cell population proliferation positive regulation of neuron projection development positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation forebrain development negative regulation of extrinsic apoptotic signaling pathway in absence of ligand T cell receptor signaling pathway cell migration viral process innate immune response positive regulation of GTPase activity phosphatidylinositol phosphate biosynthetic process regulation of phosphatidylinositol 3-kinase signaling protein phosphorylation central nervous system development regulation of peptidyl-tyrosine phosphorylation positive regulation of protein targeting to membrane positive regulation of neuron death negative regulation of dendritic spine maintenance response to amyloid-beta regulation of calcium ion import across plasma membrane response to singlet oxygen heart process negative regulation of hydrogen peroxide biosynthetic process cytokine-mediated signaling pathway positive regulation of tyrosine phosphorylation of STAT protein response to hydrogen peroxide modulation of chemical synaptic transmission positive regulation of protein kinase B signaling dendritic spine maintenance regulation of glutamate receptor signaling pathway negative regulation of oxidative stress-induced cell death positive regulation of non-membrane spanning protein tyrosine kinase activity cellular response to L-glutamate cellular response to glycine positive regulation of protein localization to membrane positive regulation of cysteine-type endopeptidase activity cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2534 14360 Ensembl ENSG00000010810 ENSMUSG00000019843 UniProt P06241 P39688 RefSeq (mRNA) NM_001242779 NM_002037 NM_153047 NM_153048 NM_001370529 NM_001122892 NM_001122893 NM_008054 RefSeq (protein) NP_002028 NP_694592 NP_694593 NP_001357458 NP_001116364 NP_001116365 NP_032080 Location (UCSC) Chr 6: 111.66 – 111.87 Mb Chr 10: 39.37 – 39.57 Mb PubMed search [3] [4]
Wikidata
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Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534)^[5] is an enzyme that in humans is encoded by the FYN gene.^[6]

Fyn is a 59-kDa member of the Src family of kinases typically associated with T-cell and neuronal signaling in development and normal cell physiology. Disruptions in these signaling pathways often have implications in the formation of a variety of cancers. By definition as a proto-oncogene, Fyn codes for proteins that help regulate cell growth. Changes in its DNA sequence transform it into an oncogene that leads to the formation of a different protein with implications for normal cell regulation.^[5][7]

Fyn is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.^[8]