FYVE domain

FYVE zinc finger
Early endosome antigen 1 (EEA1) dimer with lipids.[1]
Identifiers
SymbolFYVE
PfamPF01363
InterProIPR000306
PROSITEPDOC50178
SCOP21vfy / SCOPe / SUPFAM
OPM superfamily59
OPM protein1vfy
CDDcd00065
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind phosphatidylinositol 3-phosphate,[2] in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH-dependent manner.[3] The FYVE domain has been connected to vacuolar protein sorting and endosome function.[4]

  1. ^ Dumas JJ, Merithew E, Sudharshan E, et al. (November 2001). "Multivalent endosome targeting by homodimeric EEA1". Mol. Cell. 8 (5): 947–58. doi:10.1016/S1097-2765(01)00385-9. PMID 11741531.
  2. ^ Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R (July 1998). "FYVE fingers bind PtdIns(3)P". Nature. 394 (6692): 432–3. doi:10.1038/28767. PMID 9697764. S2CID 4385768.
  3. ^ He J, Vora M, Haney RM, et al. (September 2009). "Membrane insertion of the FYVE domain is modulated by pH". Proteins. 76 (4): 852–60. doi:10.1002/prot.22392. PMC 2909462. PMID 19296456.
  4. ^ Leevers SJ, Vanhaesebroeck B, Waterfield MD (April 1999). "Signalling through phosphoinositide 3-kinases: the lipids take centre stage". Curr. Opin. Cell Biol. 11 (2): 219–25. doi:10.1016/S0955-0674(99)80029-5. PMID 10209156.