Factor V

F5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesF5, FVL, PCCF, RPRGL1, THPH2, coagulation factor V
External IDsOMIM: 612309; MGI: 88382; HomoloGene: 104; GeneCards: F5; OMA:F5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000130

NM_007976

RefSeq (protein)

NP_000121

NP_032002

Location (UCSC)Chr 1: 169.51 – 169.59 MbChr 1: 163.98 – 164.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Coagulation factor V (Factor V), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by F5 gene.[5] In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor.[5] Factor V deficiency leads to predisposition for hemorrhage, while some mutations (most notably factor V Leiden) predispose for thrombosis.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198734Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026579Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "F5 gene: MedlinePlus Genetics". medlineplus.gov. Retrieved 9 May 2024.