Factor VII

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F7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YT7, 1BF9, 1CVW, 1DAN, 1DVA, 1F7E, 1F7M, 1FAK, 1FF7, 1FFM, 1J9C, 1JBU, 1KLI, 1KLJ, 1O5D, 1QFK, 1W0Y, 1W2K, 1W7X, 1W8B, 1WQV, 1WSS, 1WTG, 1WUN, 1WV7, 1YGC, 1Z6J, 2A2Q, 2AEI, 2AER, 2B7D, 2B8O, 2BZ6, 2C4F, 2EC9, 2F9B, 2FIR, 2FLB, 2FLR, 2PUQ, 2ZP0, 2ZWL, 2ZZU, 3ELA, 3TH2, 3TH3, 3TH4, 4IBL, 4ISH, 4ISI, 4JYU, 4JYV, 4JZD, 4JZE, 4JZF, 4NA9, 4NG9, 4NGA, 4X8S, 4X8T, 4X8U, 4X8V, 4YT6, 4ZXX, 4ZXY, 4Z6A, 4ZMA, 4YLQ, 5I46
Identifiers
Aliases	F7, SPCA, coagulation factor VII
External IDs	OMIM: 613878; MGI: 109325; HomoloGene: 7710; GeneCards: F7; OMA:F7 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q34 Start 113,105,788 bp[1] End 113,120,685 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 5.73 cM Start 13,076,034 bp[2] End 13,085,809 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver tendon of biceps brachii testicle ventral tegmental area secondary oocyte visceral pleura pancreatic ductal cell deltoid muscle jejunum retinal pigment epithelium Top expressed in left lobe of liver right lung lobe yolk sac decidua embryo entorhinal cortex stroma of bone marrow carotid body Ileal epithelium choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding endopeptidase activity peptidase activity protein binding serine-type peptidase activity hydrolase activity serine-type endopeptidase activity signaling receptor binding Cellular component vesicle endoplasmic reticulum lumen plasma membrane extracellular region Golgi lumen extracellular space serine-type peptidase complex collagen-containing extracellular matrix Biological process hemostasis positive regulation of protein kinase B signaling response to organic cyclic compound positive regulation of cell migration positive regulation of platelet-derived growth factor receptor signaling pathway proteolysis response to estrogen positive regulation of leukocyte chemotaxis endoplasmic reticulum to Golgi vesicle-mediated transport response to vitamin K positive regulation of blood coagulation response to nutrient levels animal organ regeneration response to growth hormone response to hormone blood coagulation, extrinsic pathway positive regulation of positive chemotaxis response to thyroid hormone protein processing blood coagulation response to 2,3,7,8-tetrachlorodibenzodioxine response to estradiol response to carbon dioxide response to genistein response to cholesterol circadian rhythm response to thyroxine response to Thyroid stimulating hormone response to hypoxia response to anticoagulant response to astaxanthin response to thyrotropin-releasing hormone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2155 14068 Ensembl ENSG00000057593 ENSMUSG00000031443 UniProt P08709 P70375 RefSeq (mRNA) NM_000131 NM_001267554 NM_019616 NM_010172 RefSeq (protein) NP_000122 NP_001254483 NP_062562 NP_034302 Location (UCSC) Chr 13: 113.11 – 113.12 Mb Chr 8: 13.08 – 13.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Coagulation factor VII (EC 3.4.21.21, formerly known as proconvertin) is a protein involved in coagulation and, in humans, is encoded by gene F7. It is an enzyme of the serine protease class. Once bound to tissue factor released from damaged tissues, it is converted to factor VIIa (or blood-coagulation factor VIIa, activated blood coagulation factor VII), which in turn activates factor IX and factor X.

Using genetic recombination a recombinant factor VIIa (eptacog alfa) (trade names include NovoSeven) has been approved by the FDA for the control of bleeding in hemophilia.^[5] It is sometimes used unlicensed in severe uncontrollable bleeding, although there have been safety concerns. A biosimilar form of recombinant activated factor VII (AryoSeven) is also available, but does not play any considerable role in the market.

In April 2020, the US FDA approved a new rFVIIa product, eptacog beta (SEVENFACT), the first bypassing agent (BPA) approved in more than 2 decades. As an rFVIIa product, eptacog beta works in a complex with tissue factor to activate factor X to Xa, thereby bypassing FVIII and FIX. The activation of Factor X to Xa initiates the coagulation cascade’s common pathway, leading to clot formation at the site of hemorrhage. Activated FVII binds to endothelial protein C receptor (EPCR), which enhances hemostasis.14 One study showed that eptacog beta binds to EPCR with 25% to 30% more affinity than eptacog alfa, displacing protein C from EPCR binding sites and downregulating activated protein C generation, contributing to its hemostatic effect.