Factor X

F10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesF10, FX, FXA, coagulation factor X
External IDsOMIM: 613872; MGI: 103107; HomoloGene: 30976; GeneCards: F10; OMA:F10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000504
NM_001312674
NM_001312675

NM_001242368
NM_007972

RefSeq (protein)

NP_000495
NP_001299603
NP_001299604

NP_001229297
NP_031998

Location (UCSC)Chr 13: 113.12 – 113.15 MbChr 8: 13.09 – 13.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Coagulation factor X (EC 3.4.21.6), or Stuart factor, is an enzyme of the coagulation cascade, encoded in humans by F10 gene.[5] It is a serine endopeptidase (protease group S1, PA clan). Factor X is synthesized in the liver and requires vitamin K for its synthesis.

Factor X is activated, by hydrolysis, into factor Xa by both factor IX with its cofactor, factor VIII in a complex known as intrinsic pathway; and factor VII with its cofactor, tissue factor in a complex known as extrinsic pathway.[6] It is therefore the first member of the final common pathway or thrombin pathway.

It acts by cleaving prothrombin in two places (an Arg-Thr and then an Arg-Ile bond), which yields the active thrombin. This process is optimized when factor Xa is complexed with activated co-factor V in the prothrombinase complex.

Factor Xa is inactivated by protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). The affinity of this protein for factor Xa is increased 1000-fold by the presence of protein Z, while it does not require protein Z for inactivation of factor XI. Defects in protein Z lead to increased factor Xa activity and a propensity for thrombosis. The half life of factor X is 40–45 hours.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126218Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031444Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "F10 gene: MedlinePlus Genetics". medlineplus.gov.
  6. ^ Camire RM (August 2021). "Blood coagulation factor X: molecular biology, inherited disease, and engineered therapeutics". Journal of Thrombosis and Thrombolysis. 52 (2): 383–390. doi:10.1007/s11239-021-02456-w. PMC 8531165. PMID 33886037.