Factor XII

F12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BDW, 4BDX, 4XDE, 4XE4
Identifiers
Aliases	F12, HAE3, HAEX, HAF, coagulation factor XII
External IDs	OMIM: 610619; MGI: 1891012; HomoloGene: 425; GeneCards: F12; OMA:F12 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,416,583 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,574,606 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gingival epithelium; ; mucosa of transverse colon; ; testicle; ; endothelial cell; ; middle temporal gyrus; ; epithelium of esophagus; ; nucleus accumbens; ; caudate nucleus; ; putamen;
	Top expressed in
	lobe of liver; ; left lobe of liver; ; granulocyte; ; morula; ; embryo; ; fetal liver hematopoietic progenitor cell; ; spermatid; ; sexually immature organism; ; abdominal wall; ; human fetus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	misfolded protein binding; peptidase activity; protein binding; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity; calcium ion binding;
Cellular component	plasma membrane; extracellular region; extracellular exosome; extracellular space; rough endoplasmic reticulum; collagen-containing extracellular matrix;
Biological process	hemostasis; blood coagulation, intrinsic pathway; response to misfolded protein; positive regulation of plasminogen activation; fibrinolysis; zymogen activation; protein processing; protein autoprocessing; proteolysis; positive regulation of blood coagulation; positive regulation of fibrinolysis; innate immune response; regulation of blood coagulation; plasma kallikrein-kinin cascade; Factor XII activation; blood coagulation;
	Sources:Amigo / QuickGO
Orthologs
	2161
	58992
	ENSG00000131187
	ENSMUSG00000021492
	P00748
	Q80YC5
	NM_000505
	NM_021489
	NP_000496
	NP_067464
	Wikidata
View/Edit Human	View/Edit Mouse

Coagulation factor XII, also known as Hageman factor, is a plasma protein involved in coagulation. It is the zymogen form of factor XIIa (EC 3.4.21.38), an enzyme of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by F12 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131187 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021492 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cool DE, MacGillivray RT (October 1987). "Characterization of the human blood coagulation factor XII gene. Intron/exon gene organization and analysis of the 5'-flanking region". The Journal of Biological Chemistry. 262 (28): 13662–13673. doi:10.1016/S0021-9258(19)76478-3. PMID 2888762.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131187 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021492 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2888762-5] Cool DE, MacGillivray RT (October 1987). "Characterization of the human blood coagulation factor XII gene. Intron/exon gene organization and analysis of the 5'-flanking region". The Journal of Biological Chemistry. 262 (28): 13662–13673. doi:10.1016/S0021-9258(19)76478-3. PMID 2888762.

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