Familial thoracic aortic aneurysm | |
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Other names | Familial aortic dissection, cystic medial necrosis of aorta[1] |
Micrograph showing cystic medial degeneration, the histologic correlate of familial thoracic aortic aneurysms. The image shows abundant basophilic ground substance in the tunica media (blue at top of image) and disruption of the elastic fibers. The tunica adventitia (yellow at bottom of image) with vaso vasorum is also seen. Movat's stain. |
Familial thoracic aortic aneurysm is an autosomal dominant[1] disorder of large arteries.
There is an association between familial thoracic aortic aneurysm and Marfan syndrome as well as other hereditary connective tissue disorders.