Farnesoid X receptor

NR1H4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OSH, 3BEJ, 3DCT, 3DCU, 3FLI, 3FXV, 3GD2, 3HC5, 3HC6, 3L1B, 3OKH, 3OKI, 3OLF, 3OMK, 3OMM, 3OOF, 3OOK, 3RUT, 3RUU, 3RVF, 3P88, 3P89, 4OIV, 4WVD, 4QE6, 4QE8
Identifiers
Aliases	NR1H4, BAR, FXR, HRR-1, HRR1, RIP14, nuclear receptor subfamily 1 group H member 4, PFIC5
External IDs	OMIM: 603826; MGI: 1352464; HomoloGene: 3760; GeneCards: NR1H4; OMA:NR1H4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.1 Start 100,473,708 bp[1] End 100,564,414 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C2|10 44.98 cM Start 89,290,096 bp[2] End 89,369,447 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver mucosa of ileum right adrenal gland right adrenal cortex oocyte left adrenal gland left adrenal cortex jejunal mucosa duodenum secondary oocyte Top expressed in right kidney epithelium of small intestine ileum left lobe of liver human kidney proximal tubule Ileal epithelium Paneth cell jejunum migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding DNA binding transcription corepressor activity DNA-binding transcription factor activity transcription coactivator activity zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding retinoid X receptor binding steroid hormone receptor activity bile acid binding protein binding nuclear receptor binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding chenodeoxycholic acid binding transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding nuclear receptor activity bile acid receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor binding nuclear receptor coactivator activity signaling receptor activity Cellular component nucleoplasm nucleus RNA polymerase II transcription regulator complex Biological process Notch signaling pathway cellular triglyceride homeostasis cellular response to organonitrogen compound regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of ammonia assimilation cycle toll-like receptor 4 signaling pathway immune system process histone H3-R17 methylation regulation of transcription by RNA polymerase II positive regulation of glutamate metabolic process intracellular bile acid receptor signaling pathway negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of low-density lipoprotein particle clearance regulation of bile acid biosynthetic process regulation of cholesterol metabolic process regulation of urea metabolic process intracellular receptor signaling pathway negative regulation of bile acid biosynthetic process cellular response to fatty acid bile acid and bile salt transport nitrogen catabolite activation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter inflammatory response innate immune response signal transduction steroid hormone mediated signaling pathway fatty acid homeostasis positive regulation of insulin receptor signaling pathway cellular response to lipopolysaccharide negative regulation of interleukin-2 production positive regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of inflammatory response glucose homeostasis negative regulation of NF-kappaB transcription factor activity positive regulation of adipose tissue development cell-cell junction assembly toll-like receptor 9 signaling pathway negative regulation of monocyte chemotactic protein-1 production bile acid metabolic process negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of tumor necrosis factor-mediated signaling pathway defense response to bacterium negative regulation of interleukin-1 production negative regulation of tumor necrosis factor production negative regulation of interleukin-6 production triglyceride homeostasis negative regulation of interferon-gamma production regulation of transcription, DNA-templated bile acid signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of phosphatidic acid biosynthetic process cholesterol homeostasis lipid metabolism multicellular organism development cell differentiation lipid homeostasis cellular glucose homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9971 20186 Ensembl ENSG00000012504 ENSMUSG00000047638 UniProt Q96RI1 Q60641 RefSeq (mRNA) NM_001206977 NM_001206978 NM_001206979 NM_001206992 NM_001206993 NM_005123 NM_001163504 NM_001163700 NM_009108 NM_001385711 RefSeq (protein) NP_001193906 NP_001193907 NP_001193908 NP_001193921 NP_001193922 NP_005114 NP_001193906.1 NP_001193908.1 NP_001156976 NP_001157172 NP_033134 NP_001372640 Location (UCSC) Chr 12: 100.47 – 100.56 Mb Chr 10: 89.29 – 89.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4), is a nuclear receptor that is encoded by the NR1H4 gene in humans.^[5][6]