Fasciculus retroflexus

The fasciculus retroflexus (FR) also known as the habenulointerpeduncular tract is a bundle of fibers located at the base of the midbrain in vertebrates.[1][2] Connected to the habenula (Hbn) and the interpeduncular nucleus (IPN), the fasciculus retroflexus is involved in a variety of bodily phenomena, some being sleep retention.[3] and drug addiction.[4] It acts as a channel through which messages are sent between the stria medullaris and the mid- and hindbrain. The fasciculus retroflexus, along with the stria medullaris, the habenula, and the medial forebrain bundle forms a unit for the transfer of neurological impulses. In this unit, the fasciculus retroflexus mediates the transfer of information for processes such as pain, pleasure, and motor control[5]

  1. ^ "Ontology Lookup Service (OLS)". www.ebi.ac.uk. Retrieved 31 December 2023.
  2. ^ Ramón y Cajal, Santiago (1999). Texture of the nervous system of man and the vertebrates. Wien: Springer. p. 82. ISBN 9783211830574.
  3. ^ Valjakka, Antti; Vartiainen, Jukka; Tuomisto, Leena; Tuomisto, Jouni T.; Olkkonen, Hannu; Airaksinen, Mauno M. (1998-09-15). "The fasciculus retroflexus controls the integrity of REM sleep by supporting the generation of hippocampal theta rhythm and rapid eye movements in rats". Brain Research Bulletin. 47 (2): 171–184. doi:10.1016/S0361-9230(98)00006-9. ISSN 0361-9230. PMID 9820735. S2CID 31900585.
  4. ^ Velasquez, Kenia; Molfese, David; Salas, Ramiro (2014). "The role of the habenula in drug addiction". Frontiers in Human Neuroscience. 8: 174. doi:10.3389/fnhum.2014.00174. ISSN 1662-5161. PMC 3975120. PMID 24734015.
  5. ^ Roman, Elena; Weininger, Joshua; Lim, Basil; Roman, Marin; Barry, Denis; Tierney, Paul; O’Hanlon, Erik; Levins, Kirk; O’Keane, Veronica; Roddy, Darren (2020-06-01). "Untangling the dorsal diencephalic conduction system: a review of structure and function of the stria medullaris, habenula and fasciculus retroflexus". Brain Structure and Function. 225 (5): 1437–1458. doi:10.1007/s00429-020-02069-8. ISSN 1863-2661. PMID 32367265. S2CID 218495735.