Fear-potentiated startle

Fear-potentiated startle (FPS) is a reflexive physiological reaction to a presented stimulus, and is an indicator of the fear reaction in an organism. The FPS response can be elicited in the face of any threatening stimulus (e.g., any object, person or situation that would cause someone to experience feelings of fear), but it can also be elicited by a neutral stimulus as a result of fear conditioning, a process that occurs when a benign stimulus comes to evoke fear and anxiety upon being paired with a traumatic or fear-provoking event. The stimulus in question is usually of auditory (e.g., loud noise) or visual (e.g., bright light) nature, and startle response measures include eyeblink rates and pulse/heart rate.[1] The negative impact of heightened FPS in the face of neutral stimuli can be treated pharmacologically, using psychotropic medications that are typically used to reduce anxiety in humans.[2] Recent literature, moreover, has implicated increased FPS responses as a correlate in posttraumatic stress disorder (PTSD) and other anxiety disorders.[3]

  1. ^ Grillon, C. & Davis, M. (1997). "Fear-potentiated startle conditioning in humans: Explicit and contextual cue conditioning following paired versus unpaired training". Psychophysiology. 34 (4): 451–458. doi:10.1111/j.1469-8986.1997.tb02389.x. PMID 9260498.
  2. ^ Davis, M.; Falls, W. A.; Campeau, S. & Kim, M. (1993). "Fear-Potentiated Startle: A Neural and Pharmacological Analysis". Behavioural Brain Research. 58 (1–2): 175–198. doi:10.1016/0166-4328(93)90102-v. PMID 8136044.
  3. ^ Lissek, S.; Biggs, A. L.; Rabin, S. J.; Cornwell, B. R.; Alvarez, R. P.; Pine, D. S. & Grillon, C. (2008). "Generalization of Conditioned Fear-Potentiated Startle in Humans: Experimental Validation and Clinical Relevance". Behaviour Research and Therapy. 46 (5): 678–687. doi:10.1016/j.brat.2008.02.005. PMC 2435484. PMID 18394587.