Fel d 1

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Allergen Fel d 1, chain 2 (P30440)
Allergen Fel d 1, chain 2 (P30440)
	Crystallographic structure of the Fel d 1 dimer, the primary allergen present in cat saliva
Identifiers
Symbol	Feld-I_B
Pfam	PF09252
Pfam clan	CL0370
InterPro	IPR015332
SCOP2	1puo / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Allergen Fel d 1, chain 1 (P30438)
Allergen Fel d 1, chain 1 (P30438)
Identifiers
Symbol	Allergen_Fel_d_I_chain1
InterPro	IPR006178

Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes.^[2]^[3]

Among cats, Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin. It is the primary allergen present on cats and kittens.^[1] ^[4] The function of the protein for cats is unknown, but it causes an IgG or IgE reaction in sensitive humans (either as an allergic or asthmatic response).

^ ^a ^b PDB: 1PUO; Kaiser L, Grönlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G (September 2003). "The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family". The Journal of Biological Chemistry. 278 (39): 37730–5. doi:10.1074/jbc.M304740200. PMID 12851385.
^ Morgenstern JP, Griffith IJ, Brauer AW, Rogers BL, Bond JF, Chapman MD, Kuo MC (November 1991). "Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9690–4. Bibcode:1991PNAS...88.9690M. doi:10.1073/pnas.88.21.9690. PMC 52784. PMID 1946388.
^ Griffith IJ, Craig S, Pollock J, Yu XB, Morgenstern JP, Rogers BL (April 1992). "Expression and genomic structure of the genes encoding FdI, the major allergen from the domestic cat". Gene. 113 (2): 263–8. doi:10.1016/0378-1119(92)90405-E. PMID 1572548.
^ Dabrowski AJ, Van der Brempt X, Soler M, Seguret N, Lucciani P, Charpin D, Vervloet D (October 1990). "Cat skin as an important source of Fel d I allergen". The Journal of Allergy and Clinical Immunology. 86 (4 Pt 1): 462–5. doi:10.1016/S0091-6749(05)80200-3. PMID 2229808.

[pmid12851385-1] PDB: 1PUO; Kaiser L, Grönlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G (September 2003). "The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family". The Journal of Biological Chemistry. 278 (39): 37730–5. doi:10.1074/jbc.M304740200. PMID 12851385.

[pmid1946388-2] Morgenstern JP, Griffith IJ, Brauer AW, Rogers BL, Bond JF, Chapman MD, Kuo MC (November 1991). "Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9690–4. Bibcode:1991PNAS...88.9690M. doi:10.1073/pnas.88.21.9690. PMC 52784. PMID 1946388.

[pmid1572548-3] Griffith IJ, Craig S, Pollock J, Yu XB, Morgenstern JP, Rogers BL (April 1992). "Expression and genomic structure of the genes encoding FdI, the major allergen from the domestic cat". Gene. 113 (2): 263–8. doi:10.1016/0378-1119(92)90405-E. PMID 1572548.

[4] Dabrowski AJ, Van der Brempt X, Soler M, Seguret N, Lucciani P, Charpin D, Vervloet D (October 1990). "Cat skin as an important source of Fel d I allergen". The Journal of Allergy and Clinical Immunology. 86 (4 Pt 1): 462–5. doi:10.1016/S0091-6749(05)80200-3. PMID 2229808.

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